Product image of Mebendazole Sameko (Mebendazole) supplied by GNH India

Mebendazole Sameko

Active Ingredient:
Mebendazole
Origin:
EU

Mebendazole Sameko (Mebendazole)

Mebendazole, the active ingredient in Mebendazole Sameko, is an anthelmintic presented as an oral dosage form for oral use. It is used to treat intestinal worm infections caused by common helminths in children and adults.
GNH India supplies Mebendazole Sameko as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sameko Farma B.V.

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Indications & Clinical Uses

Mebendazole is an anthelmintic that targets intestinal nematode infections.

  • Ascariasis: eliminates Ascaris lumbricoides worms, relieving gastrointestinal symptoms.
  • Trichuriasis: eradicates Trichuris trichiura, reducing abdominal discomfort and dysentery.
  • Hookworm infection: removes Ancylostoma duodenale and Necator americanus, improving anemia and nutrient absorption.
  • Pinworm infection: clears Enterobius vermicularis, stopping perianal itching and reinfection.

How It Works

  • Mebendazole binds to β‑tubulin in helminths, inhibiting microtubule polymerisation. This disruption impairs glucose uptake and depletes cellular energy, leading to parasite immobilisation and death while having minimal effect on human cells.

Side Effects

Mebendazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Abdominal pain: mild to moderate discomfort in the stomach area.
  • Nausea: feeling of queasiness that may precede vomiting.
  • Vomiting: expulsion of stomach contents.
  • Diarrhoea: loose or watery stools.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Liver enzyme elevation: signs of hepatic stress detectable in blood tests.
  • Neutropenia: reduced white blood cell count increasing infection risk.
  • Stevens‑Johnson syndrome: rare severe skin reaction requiring immediate medical attention.

Precautions & Warnings

Before using Mebendazole Sameko, consider the following precautions.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: avoid unless benefits outweigh potential risks to the infant.
  • Liver disease: use with caution; monitor hepatic function if indicated.
  • Drug interactions: review all concomitant medications with a pharmacist or physician.
  • Storage: Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mebendazole may interact with other medicines; awareness of interaction severity helps manage risk.

Major Interactions (Avoid)

  • Cimetidine: may increase mebendazole plasma concentrations.
  • Griseofulvin: may reduce the antiparasitic efficacy of mebendazole.
  • Carbamazepine: may lower mebendazole levels, reducing therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may affect metabolic clearance.
  • Warfarin: may enhance anticoagulant activity, requiring INR monitoring.

Frequently Asked Questions

Mebendazole Sameko is indicated for intestinal worm infections such as ascariasis, trichuriasis, hookworm infection, and pinworm infection. It works by eliminating the adult parasites that cause these conditions.

Mebendazole interferes with the parasite’s microtubule formation by binding to β‑tubulin. This blocks glucose uptake, depletes energy stores, and ultimately leads to the death of the helminth while sparing human cells.

The dosage of Mebendazole Sameko is determined by the prescribing healthcare professional based on the specific infection, patient age, weight, and clinical guidelines. Patients should follow the prescriber’s instructions exactly.

Safety data for mebendazole in pregnancy are limited, so it should only be used if the potential benefit justifies the risk. Breastfeeding mothers should avoid use unless advised otherwise by a healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mebendazole is a broad‑spectrum benzimidazole anthelmintic, often preferred for its efficacy against common intestinal nematodes and its oral administration. Alternatives like albendazole have similar mechanisms but may differ in dosing frequency and spectrum of activity.

Store Mebendazole Sameko below 25°C in its original container, protecting it from moisture and direct sunlight. This helps maintain product stability and potency throughout its shelf life.

Mebendazole Sameko is taken orally, usually with water. The exact administration schedule—single dose or multiple doses—depends on the infection being treated and is set by the prescriber.

Serious risks, though rare, include severe allergic reactions, liver enzyme elevations, neutropenia, and Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, fever, jaundice, or unexplained bleeding.

Individuals with known hypersensitivity to mebendazole or any component of the formulation should avoid it. Caution is also advised for patients with severe liver impairment, pregnant women without clear benefit, and those on interacting medications without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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