Product image of Mebeverine Ab (Mebeverine Hydrochloride) supplied by GNH India

Mebeverine Ab

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Mebeverine Ab (Mebeverine Hydrochloride)

Mebeverine, the active ingredient in Mebeverine Ab, is an antispasmodic presented as a tablet for oral use. It treats abdominal pain and cramping associated with irritable bowel syndrome and other functional bowel disorders.

GNH India supplies Mebeverine Ab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo N.V.

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Indications & Clinical Uses

  • Mebeverine is a gastrointestinal antispasmodic that acts on smooth muscle of the intestines.
  • Irritable bowel syndrome: reduces abdominal pain and cramping.
  • Functional bowel disorders: alleviates irregular bowel movements and discomfort.
  • Abdominal pain and cramping: provides symptomatic relief in various non‑ulcer dyspepsia contexts.

How It Works

  • Mebeverine exerts a direct antispasmodic effect on intestinal smooth muscle, primarily by inhibiting calcium influx into muscle cells. This reduction in intracellular calcium decreases muscle contractility, leading to relaxation of the gastrointestinal tract and relief of spasm‑related symptoms.

Side Effects

Mebeverine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Dry mouth
  • Nausea
  • Headache
  • Dizziness
  • Mild abdominal discomfort
  • Fatigue

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling
  • Severe hypotension
  • Cardiac arrhythmias (very rare)
  • Hepatic enzyme elevations
  • Persistent severe abdominal pain
  • Anaphylaxis (extremely rare)

Precautions & Warnings

  • Before prescribing Mebeverine, clinicians should consider several safety aspects.
  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: assess risk versus benefit; limited data available.
  • Severe hepatic impairment: use with caution; monitor liver function.
  • Renal impairment: no specific dosage adjustment, but monitor renal status.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mebeverine may interact with other medicines; awareness helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) – may increase plasma levels.
  • Anticholinergic agents – additive antispasmodic effect may cause excessive GI slowdown.

Moderate Interactions (Monitor Closely)

  • Other antispasmodics – risk of additive side effects.
  • Antihypertensives – possible additive hypotensive effect.
  • Diuretics – monitor electrolytes if combined with high doses.

Frequently Asked Questions

Mebeverine Ab is prescribed to relieve abdominal pain, cramping, and irregular bowel movements associated with irritable bowel syndrome, functional bowel disorders, and other non‑ulcer dyspepsia conditions. It works by relaxing the smooth muscle of the gastrointestinal tract, helping to reduce spasm‑related discomfort.

Mebeverine hydrochloride acts directly on intestinal smooth muscle, inhibiting calcium influx into the cells. This reduces muscle contractility, leading to relaxation of the gastrointestinal tract and alleviation of spasms that cause pain and cramping.

The dosage of Mebeverine Ab is individualized by the prescribing healthcare professional based on the patient’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for mebeverine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mebeverine differs from many anticholinergic antispasmodics because it does not have significant anticholinergic activity, reducing the risk of dry mouth, blurred vision, and urinary retention. Its direct smooth‑muscle relaxation offers comparable efficacy with a generally more favorable side‑effect profile.

Store at ambient temperature: keep the tablets in the original container, protect from moisture, heat, and direct sunlight. Do not store in bathrooms or near kitchen appliances that generate excess humidity.

Mebeverine Ab is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless the prescriber provides specific instructions to do otherwise.

Serious but rare risks include severe allergic reactions such as rash, swelling, or anaphylaxis, and hypotension that may lead to dizziness or fainting. Patients should seek immediate medical attention if they experience any signs of a severe reaction.

Mebeverine Ab is contraindicated in patients with known hypersensitivity to mebeverine or any excipients in the formulation. Caution is advised for individuals with severe hepatic impairment, and it should be avoided in pregnancy unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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