Product image of Mebeverine Hydrochloride Aspire Pharma (Mebeverine Hydrochloride) supplied by GNH India

Mebeverine Hydrochloride Aspire Pharma

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Mebeverine Hydrochloride Aspire Pharma (Mebeverine Hydrochloride)

Mebeverine Hydrochloride, the active ingredient in Mebeverine Hydrochloride Aspire Pharma, is an antispasmodic (smooth muscle relaxant) presented as an oral dosage form for oral use. It treats irritable bowel syndrome and related functional bowel disorders in adults.

GNH India supplies Mebeverine Hydrochloride Aspire Pharma as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspire Pharma Limited

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Indications & Clinical Uses

  • Mebeverine Hydrochloride is a gastrointestinal antispasmodic used to manage conditions characterized by smooth‑muscle spasm.
  • Irritable bowel syndrome (IBS): reduces abdominal pain, cramping and altered bowel habits associated with IBS.
  • Functional bowel disorders: alleviates discomfort and irregular motility in functional gastrointestinal conditions.
  • Gastrointestinal smooth‑muscle spasm: relaxes spastic segments of the gut, improving passage of contents and decreasing pain.

How It Works

  • Mebeverine Hydrochloride acts by directly relaxing gastrointestinal smooth muscle, likely through inhibition of calcium influx and modulation of muscarinic receptors. This reduces the intensity of muscle contractions, thereby decreasing spasm‑related pain and improving bowel motility without affecting normal peristalsis.

Side Effects

Mebeverine Hydrochloride may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dry mouth
  • Nausea or mild stomach upset
  • Headache
  • Dizziness
  • Fatigue
  • Mild skin rash

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Persistent tachycardia or palpitations
  • Significant hypotension
  • Hepatic dysfunction (elevated liver enzymes)
  • Acute urinary retention
  • Severe skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Pregnancy: safety not established; use only if clearly needed.
  • Breastfeeding: unknown excretion; weigh benefits against potential risks.
  • Renal or hepatic impairment: monitor clinical response and adjust if necessary.
  • Drug interactions: review concomitant medications for potential interactions.
  • Elderly patients: start at lower dose and monitor for adverse effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mebeverine Hydrochloride can interact with other medicines; awareness of the interaction level helps guide monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) – may increase plasma levels.
  • Anticholinergic agents – additive reduction of gut motility.

Moderate Interactions (Monitor Closely)

  • Other antispasmodics – risk of excessive smooth‑muscle relaxation.
  • Antihypertensives – possible additive hypotensive effect.
  • Drugs affecting electrolyte balance – monitor for arrhythmias.

Frequently Asked Questions

Mebeverine Hydrochloride is prescribed to relieve abdominal pain, cramping and irregular bowel movements caused by irritable bowel syndrome, functional bowel disorders and other conditions involving gastrointestinal smooth‑muscle spasm.

The drug relaxes smooth muscle in the gastrointestinal tract by inhibiting calcium influx and modulating muscarinic receptors, which reduces the intensity of spasms and associated pain without impairing normal peristalsis.

The dosage of Mebeverine Hydrochloride is determined by the prescribing clinician based on the patient’s condition, severity of symptoms and individual response. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety of Mebeverine Hydrochloride in pregnancy and lactation has not been conclusively established. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other antispasmodics such as hyoscine or dicyclomine, Mebeverine has a more selective action on gastrointestinal smooth muscle and a lower incidence of anticholinergic side effects like dry mouth and blurred vision, making it a preferred option for many patients with IBS.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture, heat and direct sunlight to maintain stability and potency.

Mebeverine Hydrochloride is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, significant drops in blood pressure, persistent tachycardia, hepatic dysfunction and severe skin reactions like Stevens‑Johnson syndrome. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to mebeverine or any of its excipients should avoid the drug. Caution is also advised for individuals with severe hepatic or renal impairment, uncontrolled cardiovascular disease, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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