Mebeverine Hydrochloride Aspire Pharma (Malta) (Mebeverine Hydrochloride)

Mebeverine Hydrochloride acts on gastrointestinal smooth muscle to alleviate spasm in several functional bowel conditions.

• Irritable bowel syndrome: reduces abdominal pain and cramping associated with IBS.
• Functional bowel disorders: improves bowel habit regularity and lessens discomfort.
• Intestinal colic: eases acute colicky episodes by relaxing intestinal muscle spasms.

• Mebeverine Hydrochloride directly inhibits calcium influx into gastrointestinal smooth‑muscle cells, leading to relaxation of the muscle fibers without anticholinergic activity. By stabilising the muscle membrane, it diminishes spontaneous contractions and spasm, thereby improving motility and reducing pain associated with functional bowel disorders. The effect is localized to the gut, and the drug does not significantly affect the central nervous system or cardiac conduction.

Mebeverine Hydrochloride may be associated with several adverse reactions, most of which are mild and reversible.

Common Side Effects

• Nausea: mild stomach upset.
• Dry mouth: reduced salivation.
• Headache: transient cranial discomfort.
• Dizziness: light‑headed sensation.
• Abdominal pain: mild discomfort in the gut.
• Fatigue: feeling of tiredness.

Serious or Rare Side Effects

• Allergic skin reaction: rash, itching, or hives.
• Hepatotoxicity: signs of liver injury such as jaundice.
• Severe hypersensitivity: anaphylactic reactions requiring emergency care.
• Cardiac arrhythmia: irregular heartbeat (very rare).

Before prescribing Mebeverine Hydrochloride, clinicians should consider several precautionary measures to ensure patient safety.

• Assess renal function: adjust use in patients with severe renal impairment.
• Monitor hepatic function: watch for signs of liver toxicity during therapy.
• Avoid in known hypersensitivity: discontinue if allergic reactions occur.
• Use cautiously in the elderly: increased susceptibility to dizziness and falls.
• Review concomitant medications: consider potential drug interactions.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Mebeverine Hydrochloride can interact with other medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors: may increase mebeverine plasma levels, raising risk of side effects.
• Anticholinergic agents: can counteract the smooth‑muscle relaxing effect.

Moderate Interactions (Monitor Closely)

• Tricyclic antidepressants: may enhance anticholinergic burden.
• Other antispasmodics: additive muscle‑relaxant effects could cause excessive GI slowing.
• Antihistamines: potential for increased sedation or dry mouth.
• Beta‑blockers: may alter cardiovascular response in susceptible patients.