Product image of Mebeverine Hydrochloride Syri (Mebeverine Hydrochloride) supplied by GNH India

Mebeverine Hydrochloride Syri

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Mebeverine Hydrochloride Syri (Mebeverine Hydrochloride)

Mebeverine Hydrochloride, the active ingredient in Mebeverine Hydrochloride Syri, is an antispasmodic presented as a standard strength oral tablet for oral use. It treats irritable bowel syndrome and functional bowel disorders in adults.

GNH India supplies Mebeverine Hydrochloride Syri as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Syri Limited T/A Thame Laboratories

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Indications & Clinical Uses

Mebeverine Hydrochloride acts on gastrointestinal smooth muscle to relieve spasm and related discomfort.

  • Irritable bowel syndrome: reduces abdominal pain, cramping and irregular bowel movements.
  • Functional bowel disorders: improves stool consistency and eases discomfort associated with dysmotility.
  • Gastrointestinal spasm: relaxes smooth muscle, helping to normalize transit and lessen urgency.

How It Works

  • Mebeverine Hydrochloride directly relaxes gastrointestinal smooth muscle, likely by blocking calcium influx through voltage‑dependent calcium channels. This action reduces muscle tone without anticholinergic effects, allowing the gut to contract more normally and decreasing painful spasms associated with functional bowel conditions.

Side Effects

Mebeverine Hydrochloride is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Nausea: mild, transient stomach upset.
  • Headache: occasional dull or throbbing pain.
  • Dizziness: brief light‑headed sensation.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling or difficulty breathing.
  • Palpitations: irregular or rapid heartbeat.
  • Severe abdominal pain: persistent or worsening discomfort.
  • Hepatic dysfunction: abnormal liver enzyme levels.
  • Blood dyscrasias: unexplained bruising or bleeding.

Precautions & Warnings

Before using Mebeverine Hydrochloride, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Liver impairment: use with caution; monitor hepatic function if indicated.
  • Elderly patients: start at the lowest effective dose and monitor for adverse effects.
  • Drug interactions: review concomitant medications with a pharmacist.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mebeverine Hydrochloride may interact with other medicines; awareness of the type of interaction helps manage risk.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase plasma levels of mebeverine.
  • Anticholinergic agents: combined effect could exacerbate constipation.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., SSRIs): monitor for enhanced gastrointestinal side effects.
  • Antihistamines: may increase risk of dry mouth.
  • Diuretics: watch for electrolyte disturbances.
  • Anticoagulants: observe for any changes in bleeding tendency.

Frequently Asked Questions

Mebeverine Hydrochloride Syri is used to relieve abdominal pain, cramping and irregular bowel habits associated with irritable bowel syndrome and other functional bowel disorders by relaxing the smooth muscle of the gastrointestinal tract.

The drug acts directly on gastrointestinal smooth muscle, likely blocking calcium channels, which reduces muscle tone and spasm without anticholinergic activity, allowing more normal gut motility and less pain.

The appropriate dose is determined by the prescribing clinician based on the individual’s condition, age, and response. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mebeverine differs from many antispasmodics because it relaxes gut smooth muscle without anticholinergic effects, which may result in fewer dry‑mouth or urinary‑retention side effects compared with agents such as hyoscine or dicyclomine.

Store the tablets at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date.

The medication is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their healthcare provider.

Serious risks, though rare, include allergic reactions such as rash, swelling or breathing difficulty, severe abdominal pain, palpitations, and hepatic dysfunction. Any of these symptoms should prompt immediate medical attention.

Individuals with known hypersensitivity to mebeverine or any of the tablet’s excipients, and patients with severe liver impairment should avoid using the product unless advised otherwise by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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