Mebeverine Teva Uk (Mebeverine Hydrochloride)

Mebeverine acts on the smooth muscle of the gastrointestinal tract to reduce spasm and discomfort in several functional bowel conditions.

• Irritable bowel syndrome: alleviates abdominal cramping and irregular bowel movements.
• Functional bowel disorders: reduces painful spasms and improves bowel habit regularity.
• Spastic colon: relaxes colonic smooth muscle to lessen colicky pain.

• Mebeverine directly relaxes gastrointestinal smooth muscle, likely by inhibiting calcium influx into the muscle cells and modulating muscarinic receptors. This dual action reduces the intensity of muscle contractions, thereby decreasing spasm‑related pain and discomfort without significantly affecting normal motility.

Mebeverine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Dry mouth: reduced salivation.
• Headache: transient cranial discomfort.
• Dizziness: light‑headed sensation.
• Abdominal pain: mild discomfort.
• Constipation: reduced bowel movements.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, or swelling.
• Severe skin eruption: Stevens‑Johnson‑like presentation.
• Angioedema: swelling of face, lips, or tongue.
• Cardiac arrhythmia: irregular heartbeat (rare).

Before prescribing Mebeverine, clinicians should consider several safety aspects.

• Pregnancy: safety not established; avoid unless clearly needed.
• Breastfeeding: unknown excretion; weigh benefits against potential risks.
• Hepatic impairment: use with caution; monitor liver function.
• Renal impairment: dose adjustment may be required in severe cases.
• Hypersensitivity: discontinue if allergic signs appear.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Mebeverine may interact with other medicines that affect smooth muscle tone or metabolism.

Major Interactions (Avoid)

• Potent CYP3A4 inhibitors: may increase mebeverine plasma levels.
• Other anticholinergic agents: additive antispasmodic effect can cause excessive dryness.
• Gastrointestinal motility agents: combined use may lead to profound motility changes.

Moderate Interactions (Monitor Closely)

• Antihistamines: may enhance dry‑mouth sensation.
• Antidepressants (SSRIs, TCAs): monitor for increased gastrointestinal side effects.
• Anticoagulants: observe for any unexpected bleeding, though evidence is limited.