Product image of Mebeverine Zydus (Mebeverine Hydrochloride) supplied by GNH India

Mebeverine Zydus

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Mebeverine Zydus (Mebeverine Hydrochloride)

Mebeverine Hydrochloride, the active ingredient in Mebeverine Zydus, is an antispasmodic (smooth muscle relaxant) presented as an oral tablet for oral use. It is employed to alleviate abdominal discomfort and altered bowel habits associated with irritable bowel syndrome and other functional bowel disorders.

GNH India supplies Mebeverine Zydus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Zydus France

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Indications & Clinical Uses

Mebeverine Hydrochloride acts on gastrointestinal smooth muscle to relieve spasm and related symptoms. It is indicated for:

  • Irritable bowel syndrome: reduces abdominal pain, cramping and irregular bowel movements.
  • Functional bowel disorders: improves overall bowel habit and decreases discomfort.
  • Spastic colon: alleviates colonic smooth‑muscle spasms and associated pain.

How It Works

  • Mebeverine Hydrochloride relaxes gastrointestinal smooth muscle by inhibiting calcium influx into the muscle cells and antagonising muscarinic receptors. This dual action reduces muscle contractility without affecting normal peristalsis, thereby decreasing spasms and abdominal pain associated with functional bowel conditions.

Side Effects

Mebeverine Hydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dry mouth: reduced salivation causing throat discomfort.
  • Headache: transient cranial pain.
  • Dizziness: occasional light‑headed sensation.
  • Abdominal cramps: mild lingering discomfort.
  • Constipation: reduced bowel frequency.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, or angioedema.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Stevens‑Johnson syndrome: severe skin blistering.

Precautions & Warnings

Before prescribing Mebeverine Hydrochloride, consider the following precautions:

  • Pregnancy: safety not established; avoid unless clearly needed.
  • Breastfeeding: unknown safety; weigh benefits against potential risks.
  • Renal impairment: use with caution and monitor renal function.
  • Elderly patients: increased susceptibility to side effects; start at lowest effective dose.
  • Drug interactions: review concomitant medications for potential additive antispasmodic effects.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Mebeverine Hydrochloride may interact with other medicines. Review patient medication lists carefully.

Major Interactions (Avoid)

  • Other antispasmodics: risk of excessive smooth‑muscle relaxation.
  • Strong CYP3A4 inhibitors: may increase mebeverine plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Antihistamines: possible additive sedation.
  • Beta‑blockers: monitor heart rate and blood pressure.
  • Diuretics: watch for electrolyte disturbances.
  • Anticholinergic agents: enhanced anticholinergic burden.
  • Oral contraceptives: potential alteration of hormone levels.

Frequently Asked Questions

Mebeverine Zydus contains mebeverine hydrochloride, an antispasmodic indicated for the relief of abdominal pain, cramping and irregular bowel movements associated with irritable bowel syndrome and other functional bowel disorders.

Mebeverine relaxes gastrointestinal smooth muscle by blocking calcium entry into muscle cells and antagonising muscarinic receptors, which reduces spasms without impairing normal intestinal motility.

The prescribed dose of Mebeverine Zydus is determined by the treating physician based on the patient’s condition, severity of symptoms and clinical response. Patients should follow the prescriber’s instructions exactly.

Safety data for mebeverine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mebeverine is a direct smooth‑muscle relaxant that does not possess anticholinergic activity, unlike some alternatives such as hyoscine. This profile often results in fewer dry‑mouth or blurred‑vision side effects, making it a preferred option for patients sensitive to anticholinergic effects.

Store Mebeverine Zydus at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Mebeverine Zydus is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious but rare risks include severe allergic reactions such as rash, angioedema, Stevens‑Johnson syndrome, marked hypotension, cardiac arrhythmias and significant liver enzyme elevations. Patients should seek immediate medical attention if any of these symptoms develop.

Mebeverine Zydus should be avoided in patients with known hypersensitivity to mebeverine or any excipients, and used with caution in those with severe hepatic or renal impairment. It is also contraindicated when an alternative diagnosis requiring different therapy is suspected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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