Product image of Mebeverinehydrochloride Aurobindo (Mebeverine Hydrochloride) supplied by GNH India

Mebeverinehydrochloride Aurobindo

Active Ingredient:
Mebeverine Hydrochloride
Origin:
EU

Mebeverinehydrochloride Aurobindo (Mebeverine Hydrochloride)

Mebeverine Hydrochloride, the active ingredient in Mebeverinehydrochloride Aurobindo, is an antispasmodic presented as an unspecified strength tablet for oral use. It relieves abdominal pain and irregular bowel habits associated with irritable bowel syndrome and other functional bowel disorders in adult patients.

GNH India supplies Mebeverinehydrochloride Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Mebeverine Hydrochloride acts on the gastrointestinal smooth muscle to reduce spasm in functional bowel conditions.

  • Irritable bowel syndrome: lessens abdominal cramping and improves stool consistency.
  • Functional bowel disorders: alleviates spasms and discomfort without affecting normal motility.
  • Spastic colon: relaxes gastrointestinal smooth muscle to diminish pain and urgency.

How It Works

  • Mebeverine Hydrochloride exerts a direct relaxant effect on gastrointestinal smooth muscle by inhibiting calcium influx and modulating intracellular signaling pathways. This action reduces hyper‑contractility and spasm while preserving normal peristaltic activity, thereby improving symptoms of functional bowel disorders without markedly altering overall gut motility.

Side Effects

Mebeverine Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dry mouth: reduced salivation.
  • Headache: occasional tension‑type pain.
  • Dizziness: brief light‑headed sensations.
  • Abdominal pain: mild discomfort.
  • Constipation: reduced bowel frequency.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, or angioedema.
  • Severe hypotension: marked drop in blood pressure.
  • Cardiac arrhythmia: rare irregular heartbeats.
  • Hepatic injury: uncommon liver enzyme elevation.

Precautions & Warnings

Before prescribing Mebeverine Hydrochloride, clinicians should consider several safety aspects.

  • Hypersensitivity: avoid in patients with known allergy to mebeverine or excipients.
  • Hepatic impairment: use with caution; monitor liver function.
  • Renal impairment: adjust if severe renal dysfunction is present.
  • Concomitant anticholinergics: monitor for additive antispasmodic effects.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Mebeverine Hydrochloride has a limited interaction profile, but some combinations require attention.

Major Interactions (Avoid)

  • None well documented: no strong contraindicated drug combinations have been identified.

Moderate Interactions (Monitor Closely)

  • Anticholinergic agents: may enhance antispasmodic effect and increase dry‑mouth risk.
  • Other antispasmodics: additive smooth‑muscle relaxation could lead to excessive GI hypomotility.
  • CYP3A4 inhibitors (e.g., ketoconazole): may raise mebeverine plasma levels.
  • CYP3A4 inducers (e.g., rifampicin): may reduce therapeutic effectiveness.

Frequently Asked Questions

Mebeverinehydrochloride Aurobindo is prescribed to relieve abdominal cramping, pain, and irregular bowel habits associated with irritable bowel syndrome and other functional bowel disorders. It works by reducing gastrointestinal smooth‑muscle spasm, helping patients achieve more regular and comfortable bowel movements.

Mebeverine Hydrochloride acts as a direct smooth‑muscle relaxant in the gastrointestinal tract. It inhibits calcium entry into smooth‑muscle cells and modulates intracellular signaling, which diminishes hyper‑contractility and spasm while preserving normal peristalsis, thereby easing symptoms of functional bowel conditions.

The appropriate dose of Mebeverinehydrochloride Aurobindo is determined by the prescribing physician based on the individual’s condition, severity of symptoms, and overall health status. Patients should follow the exact dosing instructions provided by their healthcare professional and not adjust the dose on their own.

Safety data for Mebeverinehydrochloride Aurobindo in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mebeverine differs from many anticholinergic antispasmodics because it relaxes smooth muscle without significantly affecting normal motility or causing strong anticholinergic side effects such as dry mouth or urinary retention. This profile often makes it a preferred option for patients who need spasm relief but wish to avoid pronounced anticholinergic burden.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging to protect from moisture and light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Mebeverinehydrochloride Aurobindo is taken orally, usually with a glass of water. It can be administered with or without food, but patients should follow the specific instructions given by their prescriber regarding timing relative to meals.

Serious risks, though rare, include allergic reactions such as rash, itching, or angioedema, as well as severe hypotension and cardiac arrhythmias. Patients should seek immediate medical attention if they experience any signs of an allergic response or unexplained cardiovascular symptoms.

Individuals with a known hypersensitivity to mebeverine or any of the tablet’s excipients should avoid the medication. Caution is also advised for patients with severe hepatic or renal impairment, and it should be used only under medical supervision in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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