Product image of Meboflur (Flurbiprofen) supplied by GNH India

Meboflur

Active Ingredient:
Flurbiprofen
Origin:
EU

Meboflur (Flurbiprofen)

Flurbiprofen, the active ingredient in Meboflur, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oropharyngeal use. It provides analgesic and anti‑inflammatory effects for the relief of mild to moderate pain and inflammation.

GNH India supplies Meboflur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Flurbiprofen is employed in several musculoskeletal and postoperative pain conditions, acting through inhibition of prostaglandin synthesis.
  • Rheumatoid arthritis: reduces joint inflammation and pain.
  • Osteoarthritis: alleviates joint stiffness and discomfort.
  • Post‑operative dental pain: provides short‑term relief after dental surgery.

How It Works

  • Flurbiprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin levels lower inflammation, pain signaling, and fever responses, delivering its analgesic and anti‑inflammatory actions at the site of tissue injury.

Side Effects

Flurbiprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dyspepsia: upset stomach or indigestion.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.
  • Nausea: feeling of sickness.
  • Diarrhoea: loose stools.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment: reduced kidney function.
  • Hepatotoxicity: liver enzyme elevation.
  • Severe hypersensitivity reactions: anaphylaxis or angioedema.
  • Cardiovascular events: increased risk of heart attack or stroke.
  • Blood dyscrasias: thrombocytopenia or leukopenia.

Precautions & Warnings

  • When using flurbiprofen, consider the following safety measures.
  • Assess renal function: monitor kidney parameters in patients with pre‑existing renal disease.
  • Evaluate gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding.
  • Check cardiovascular status: avoid in patients with uncontrolled hypertension or recent cardiac events.
  • Review concomitant medications: assess for additive NSAID exposure.
  • Avoid use in known hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Flurbiprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: increased gastrointestinal toxicity.
  • Corticosteroids: synergistic ulcerogenic effect.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.
  • ACE inhibitors or diuretics: possible reduction in renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: potential for increased lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.
  • Cyclosporine: enhanced nephrotoxic risk.
  • Digoxin: possible increase in serum concentrations.
  • Diabetic agents: may affect glycemic control.

Frequently Asked Questions

Meboflur contains flurbiprofen, an NSAID indicated for the relief of mild to moderate pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, and short‑term postoperative dental discomfort. It works by reducing prostaglandin‑mediated inflammation at the site of injury.

Flurbiprofen blocks the activity of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, it diminishes inflammation, pain signaling, and fever, providing its therapeutic effect.

The specific dose of Meboflur is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal or hepatic function. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of flurbiprofen in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both flurbiprofen and ibuprofen belong to the NSAID class and share a similar mechanism of COX inhibition. Flurbiprofen is generally considered slightly more potent on a milligram‑per‑milligram basis, but the choice depends on individual patient response, tolerability, and specific clinical guidelines.

Meboflur should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Meboflur is intended for oropharyngeal (oral) administration. The dosage form is taken by mouth as directed by a healthcare professional, typically with a glass of water, unless otherwise instructed.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, hepatotoxicity, severe hypersensitivity reactions such as anaphylaxis, and increased cardiovascular events like heart attack or stroke. Patients should be monitored for these events, especially if they have pre‑existing risk factors.

Meboflur should be avoided in individuals with known hypersensitivity to flurbiprofen or other NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, uncontrolled hypertension, and in patients who have recently experienced a myocardial infarction or stroke unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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