Product image of Mecolzine (Mesalazine) supplied by GNH India

Mecolzine

Active Ingredient:
Mesalazine
Origin:
EU

Mecolzine (Mesalazine)

Mesalazine, the active ingredient in Mecolzine, is a 5‑aminosalicylic acid (5‑ASA) anti‑inflammatory presented as a rectal formulation for rectal use. It is employed to treat ulcerative colitis, particularly inflammation limited to the rectum and distal colon, in adult patients.

GNH India supplies Mecolzine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑compliant shipments to global markets.

Manufacturer / TM Owner

Faes Farma, S.A.

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Indications & Clinical Uses

Mecolzine (mesalazine) is used in the management of inflammatory bowel disease, specifically ulcerative colitis, acting locally on the colonic mucosa.

  • Ulcerative colitis: reduces mucosal inflammation and promotes remission in patients with disease limited to the rectum or left colon.
  • Ulcerative proctitis: delivers topical anti‑inflammatory effect to control symptoms and heal the rectal lining.
  • Maintenance of remission: helps sustain disease‑free status after induction therapy in ulcerative colitis.

How It Works

  • Mesalazine exerts its anti‑inflammatory action by inhibiting cyclooxygenase and lipoxygenase pathways in the colonic epithelium, thereby decreasing prostaglandin and leukotriene synthesis. It also scavenges free radicals, stabilising cell membranes and reducing oxidative stress, which collectively dampen the inflammatory response in ulcerative colitis.

Side Effects

Mecolzine may cause a range of adverse reactions, most of which are mild and self‑limiting.

Common Side Effects

  • Rectal irritation or burning sensation.
  • Abdominal cramping or pain.
  • Diarrhoea or loose stools.
  • Nausea.
  • Headache.
  • Mild skin rash.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema).
  • Hepatotoxicity (elevated liver enzymes, jaundice).
  • Blood dyscrasias (neutropenia, thrombocytopenia).
  • Acute pancreatitis.
  • Renal impairment or interstitial nephritis.
  • Severe colitis flare requiring hospitalization.

Precautions & Warnings

Before initiating Mecolzine, consider the following safety measures.

  • Renal function: assess baseline kidney function and monitor periodically.
  • Hepatic status: evaluate liver enzymes prior to treatment and during therapy.
  • Blood counts: obtain complete blood count before start and monitor for cytopenias.
  • Pregnancy: use only if potential benefit justifies potential risk; data are limited.
  • Breastfeeding: weigh benefits against possible infant exposure.
  • Storage: Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Mecolzine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • High‑dose NSAIDs: can exacerbate renal toxicity.

Moderate Interactions (Monitor Closely)

  • Other 5‑ASA products: risk of additive toxicity.
  • Corticosteroids: may increase risk of gastrointestinal side effects.
  • Immunosuppressants (e.g., azathioprine): monitor for enhanced myelosuppression.

Frequently Asked Questions

Mecolzine contains mesalazine, a 5‑aminosalicylic acid that is prescribed to treat ulcerative colitis, especially disease confined to the rectum or distal colon. It helps reduce inflammation, control symptoms, and maintain remission in adult patients.

Mesalazine works locally in the colon by blocking cyclooxygenase and lipoxygenase enzymes, which lowers prostaglandin and leukotriene production. It also scavenges free radicals, stabilising cell membranes and dampening the inflammatory cascade that drives ulcerative colitis.

The prescribed dose of Mecolzine is determined by the treating physician based on disease severity, location, and patient response. Dosage instructions are individualized and should be followed exactly as written on the prescription label.

Safety data for mesalazine in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Consultation with a healthcare professional is essential before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mecolzine delivers mesalazine directly to the colonic mucosa via a rectal formulation, offering targeted anti‑inflammatory action with fewer systemic effects compared with oral 5‑ASA or systemic steroids. It is often preferred for distal disease where topical therapy provides optimal efficacy.

Mecolzine should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, heat and direct sunlight to maintain stability and potency throughout its shelf life.

Mecolzine is administered rectally, typically as an enema or suppository, according to the prescribing information. The patient should follow the instructions for insertion, timing and frequency provided by the healthcare professional.

Serious risks include severe allergic reactions such as anaphylaxis, liver toxicity, blood dyscrasias (e.g., neutropenia, thrombocytopenia), acute pancreatitis, and renal impairment. Patients should be monitored regularly for these rare but potentially life‑threatening events.

Mecolzine is contraindicated in patients with known hypersensitivity to mesalazine or any component of the formulation. It should also be avoided in individuals with severe renal or hepatic impairment unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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