Product image of Medaxonum Lido (Ceftriaxone, Lidocaine Hydrochloride) supplied by GNH India

Medaxonum Lido

Active Ingredient:
Ceftriaxone, Lidocaine Hydrochloride
Origin:
EU

Medaxonum Lido (Ceftriaxone, Lidocaine Hydrochloride)

Ceftriaxone, the active antibiotic ingredient in Medaxonum Lido, is a third‑generation cephalosporin presented as an injection for intramuscular use. Combined with lidocaine hydrochloride, the product treats severe bacterial infections such as pneumonia, meningitis and intra‑abdominal infections, while providing local anesthesia for the injection itself.

GNH India supplies Medaxonum Lido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Medaxonum Lido, containing ceftriaxone and lidocaine, is indicated for bacterial infections treated via systemic antibacterial activity and for providing local anesthesia during intramuscular injection.

  • Pneumonia: effective bacterial clearance in community‑acquired or hospital‑acquired pneumonia.
  • Meningitis: rapid eradication of causative organisms in bacterial meningitis.
  • Intra‑abdominal infections: broad‑spectrum coverage for complicated intra‑abdominal sepsis.
  • Local anesthesia for intramuscular injection: lidocaine component reduces injection‑related pain.

How It Works

  • Ceftriaxone binds to penicillin‑binding proteins, inhibiting the final steps of bacterial cell‑wall peptidoglycan synthesis, leading to cell lysis. Lidocaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, stabilising the membrane and preventing propagation of nerve impulses, thereby producing local anaesthesia at the injection site.

Side Effects

Common Side Effects

  • Injection site pain or erythema.
  • Diarrhoea or loose stools.
  • Nausea or mild vomiting.
  • Transient rash or pruritus.
  • Mild elevation of liver enzymes.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reactions.
  • Clostridioides difficile‑associated colitis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Seizures, particularly with high doses or renal impairment.
  • Hepatic dysfunction or jaundice.

Precautions & Warnings

Before using Medaxonum Lido, consider the following precautions:

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic dysfunction: observe liver enzymes during treatment.
  • Allergy to beta‑lactam antibiotics: avoid use in patients with known hypersensitivity.
  • Neonates and infants: use with caution due to altered pharmacokinetics.
  • Pregnancy Category B: prescribe only when clearly indicated.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Medaxonum Lido may interact with other medicines as follows:

Major Interactions (Avoid)

  • Calcium‑containing IV solutions: risk of insoluble precipitate formation.
  • Probenecid: can increase ceftriaxone plasma concentrations.
  • Warfarin: may potentiate anticoagulant effect and increase bleeding risk.
  • Live vaccines: concurrent use may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Aminoglycosides: additive nephrotoxicity, monitor renal function.
  • Loop diuretics: increased risk of ototoxicity when combined with lidocaine.
  • Other central nervous system depressants: may enhance systemic lidocaine toxicity.

Frequently Asked Questions

Medaxonum Lido is an injectable combination of ceftriaxone and lidocaine used to treat severe bacterial infections such as pneumonia, meningitis and intra‑abdominal sepsis, while also providing local anaesthesia to minimise discomfort during the intramuscular injection.

Ceftriaxone inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, which blocks the cross‑linking of peptidoglycan strands. This disruption weakens the cell wall, leading to bacterial lysis and death, providing broad‑spectrum antibacterial activity.

The dosage of Medaxonum Lido is determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and local guidelines. No fixed regimen is provided here; the prescriber sets the appropriate dose.

Ceftriaxone is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but a lack of well‑controlled human data. It may be used during pregnancy only if clearly needed. Lidocaine also has a favorable safety profile, but the overall decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Compared with earlier‑generation cephalosporins, ceftriaxone offers a longer half‑life, allowing once‑daily dosing, and broader coverage against Gram‑negative organisms. The addition of lidocaine distinguishes Medaxonum Lido by providing immediate local anaesthesia, which many other ceftriaxone formulations lack.

Store the product at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep it in the original packaging until use and discard any solution that appears discoloured or contains particles.

Medaxonum Lido is given by intramuscular injection using aseptic technique. The dose is prepared in a sterile syringe, injected into a large muscle (e.g., gluteus or thigh), and the lidocaine component helps reduce injection‑related pain.

Serious adverse reactions include anaphylaxis, severe allergic skin reactions such as Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and rare seizures. Patients should be monitored for signs of hypersensitivity, gastrointestinal severe diarrhea, or neurologic changes during therapy.

Patients with a known hypersensitivity to ceftriaxone, other cephalosporins, penicillins, or lidocaine should avoid the product. It is also contraindicated in individuals with a history of severe allergic reactions to beta‑lactam antibiotics or local anesthetics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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