Product image of Medazol (Metronidazole) supplied by GNH India

Medazol

Active Ingredient:
Metronidazole
Origin:
EU

Medazol (Metronidazole)

Metronidazole, the active ingredient in Medazol, is a nitroimidazole presented as an oral tablet for oral use. It treats a range of bacterial and protozoal infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Medazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Metazol (metronidazole) is employed against anaerobic bacteria and certain protozoa across several clinical conditions.

  • Bacterial vaginosis: eliminates the anaerobic flora causing vaginal discharge and odor.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving itching and discharge.
  • Amoebiasis: clears intestinal Entamoeba histolytica infection and associated dysentery.
  • Giardiasis: removes Giardia lamblia parasites, reducing diarrhea and malabsorption.
  • Anaerobic bacterial infections: treats intra‑abdominal, pelvic and skin‑soft tissue infections caused by anaerobes.
  • Clostridioides difficile infection: suppresses toxin‑producing C. difficile, aiding resolution of colitis.

How It Works

  • Metronidazole enters susceptible microbial cells and undergoes reduction of its nitro group, generating reactive nitro radicals. These free radicals interact with DNA, causing strand breaks and loss of helical structure, which inhibits nucleic acid synthesis and leads to cell death of anaerobic bacteria and susceptible protozoa.

Side Effects

Metazol may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: mild to moderate headache.
  • Abdominal pain: cramping or discomfort.
  • Dark urine: harmless discoloration of urine.

Serious or Rare Side Effects

  • Seizures: rare neurologic events requiring immediate care.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.

Precautions & Warnings

Before prescribing Metazol, clinicians should consider several safety aspects.

  • Pregnancy: use only if clearly needed; discuss risks with a healthcare provider.
  • Alcohol consumption: avoid alcohol due to a disulfiram‑like reaction.
  • Liver disease: monitor liver function; dose adjustment may be required.
  • Renal impairment: assess kidney function; dosage may need modification.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metazol can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Disulfiram: may cause severe flushing and hypotension.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: elevated lithium concentrations, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole plasma levels.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Phenytoin: may lower metronidazole concentrations, reducing efficacy.

Frequently Asked Questions

Medazol, whose active ingredient is metronidazole, is indicated for bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, various anaerobic bacterial infections, and Clostridioides difficile infection. It targets the microorganisms responsible for these conditions, helping to resolve symptoms and eradicate the infection when prescribed by a qualified clinician.

Metronidazole penetrates susceptible microbial cells and is reduced to reactive nitro radicals. These radicals damage microbial DNA by causing strand breaks and disrupting nucleic acid synthesis, which leads to cell death. This mechanism is effective against anaerobic bacteria and certain protozoa, making it useful for the infections listed under its indications.

The dosage of Medazol is individualized by the prescribing healthcare professional based on the specific infection, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions precisely and not alter the dose without medical advice.

Metronidazole is classified as a pregnancy category B drug in many regions, indicating that animal studies have not shown risk but adequate human studies are lacking. It should be used during pregnancy only if clearly needed and after consulting a healthcare provider. Metronidazole is excreted in breast milk; breastfeeding mothers should discuss risks and benefits with their clinician.

To request Medazol, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Metronidazole is a nitroimidazole that specifically targets anaerobic organisms and certain protozoa, offering a broad spectrum against these pathogens. Compared with beta‑lactam antibiotics, it provides effective coverage for anaerobes without the need for beta‑lactamase inhibitors, but it lacks activity against aerobic bacteria, so choice depends on the infection’s microbial profile.

Medazol should be stored at temperatures below 25 °C in a dry place. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. Do not store in the bathroom or near heat sources.

Medazol is supplied as oral tablets that are taken by mouth with or without food, as directed by the prescriber. The tablets should be swallowed whole with a full glass of water. Patients should not crush or chew the tablets unless specifically instructed by a healthcare professional.

Serious adverse reactions to Metazol include seizures, peripheral neuropathy, severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, and hepatotoxicity. Patients should seek immediate medical attention if they experience neurological symptoms, severe skin reactions, or signs of liver injury while taking the medication.

Medazol is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. It should also be avoided in patients with a history of severe reactions to alcohol when combined with metronidazole, and in those for whom the prescriber determines the risks outweigh the benefits, such as certain pregnant women or patients with severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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