Product image of Medazol (Metronidazole) supplied by GNH India

Medazol

Active Ingredient:
Metronidazole
Origin:
EU

Medazol (Metronidazole)

Metronidazole, the active ingredient in Medazol, is a nitroimidazole antibiotic presented as a vaginal formulation for local use. It is prescribed to treat bacterial vaginosis, trichomoniasis and other vaginal infections caused by susceptible anaerobic microorganisms in adult women.

GNH India supplies Medazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Metazol belongs to the nitroimidazole class and is used to manage infections of the vaginal tract caused by anaerobic organisms.

  • Bacterial vaginosis: eliminates overgrowth of anaerobic bacteria, reducing discharge and odor.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving itching and irritation.
  • Anaerobic vaginal infections: treats infections caused by susceptible anaerobic bacteria, promoting symptom resolution.

How It Works

  • Metronidazole enters anaerobic microbial cells and undergoes reduction of its nitro group, generating reactive nitro radicals. These free radicals interact with DNA, causing strand breakage and loss of helical structure, which inhibits nucleic acid synthesis and leads to cell death of susceptible bacteria and protozoa.

Side Effects

Metazol may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Vaginal irritation or burning
  • Itching or pruritus
  • Abnormal vaginal discharge
  • Mild nausea
  • Headache
  • Metallic taste

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, rash, swelling)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatotoxicity (jaundice, elevated liver enzymes)
  • Peripheral neuropathy (tingling, numbness)
  • Seizures
  • Severe colitis

Precautions & Warnings

Before using Medazol, consider the following safety measures.

  • Pregnancy: Category B; use only when clearly needed after risk‑benefit assessment.
  • Breastfeeding: Metronidazole is excreted in milk; consult a healthcare professional before use.
  • Alcohol: Avoid alcohol during treatment and for 48 hours after the last dose to prevent a disulfiram‑like reaction.
  • Liver or kidney impairment: Dose adjustment may be required; monitor function.
  • Allergies: Discontinue if signs of hypersensitivity appear.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metazol can interact with several medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, nausea, vomiting.
  • Warfarin: increased anticoagulant effect, risk of bleeding.
  • Lithium: elevated lithium levels, potential toxicity.
  • Carbamazepine: reduced efficacy of metronidazole.
  • Phenytoin: decreased plasma concentration of metronidazole.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase metronidazole levels.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Theophylline: increased theophylline concentrations.
  • Rifampicin: may lower metronidazole concentrations.
  • Bupropion: potential for increased side‑effects.

Frequently Asked Questions

Medazol, containing metronidazole, is prescribed for bacterial vaginosis, trichomoniasis and other vaginal infections caused by susceptible anaerobic bacteria. It works locally in the vagina to eliminate the pathogenic microorganisms responsible for these conditions.

Metronidazole penetrates anaerobic microorganisms and is reduced to reactive nitro radicals. These radicals damage DNA and other critical biomolecules, preventing nucleic acid synthesis and leading to cell death of the bacteria or protozoa causing the infection.

The dosage of Medazol is determined by the prescribing clinician based on the specific infection, severity, and patient factors. Only a qualified healthcare professional should set the dose and treatment duration.

Metronidazole is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It should be used during pregnancy only if clearly needed. The drug is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before use.

To request Medazol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Medazol (metronidazole) is a first‑line nitroimidazole antibiotic, widely used because of its proven efficacy against anaerobic bacteria. Alternatives such as clindamycin belong to a different class and may be considered when metronidazole is contraindicated or ineffective, but metronidazole remains the most commonly prescribed option.

Medazol should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain its stability and potency.

Medazol is supplied as a vaginal formulation. The prescribed dose is inserted into the vagina using the applicator or as directed by the healthcare professional, typically for a course of several days depending on the infection being treated.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, hepatotoxicity, peripheral neuropathy, seizures and severe colitis. Patients should seek immediate medical attention if they experience rash, swelling, jaundice, numbness, or persistent abdominal pain.

Medazol is contraindicated in individuals with a known hypersensitivity to metronidazole or other nitroimidazole compounds. It should also be avoided in patients with severe liver disease or those who are unable to abstain from alcohol during treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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