Product image of Medi-Exametazim (Exametazime) supplied by GNH India

Medi-Exametazim

Active Ingredient:
Exametazime
Origin:
EU

Medi-Exametazim (Exametazime)

Exametazime, the active ingredient in Medi-Exametazim, is a radiopharmaceutical presented as an injection solution for intravenous use. It enables cerebral perfusion imaging to assist diagnosis in patients with stroke, epilepsy or dementia.
GNH India supplies Medi-Exametazim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Radiopharmacy Laboratórium Kft.

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Indications & Clinical Uses

  • Medi-Exametazim is used in diagnostic imaging of cerebral blood flow for several neurological conditions.
  • Stroke evaluation: provides quantitative brain perfusion data to guide acute and sub‑acute stroke management.
  • Epilepsy assessment: visualises regional cerebral perfusion patterns that help localise seizure foci.
  • Dementia evaluation: assists in differentiating vascular from neurodegenerative causes by mapping perfusion deficits.

How It Works

  • Exametazime acts as a chelating ligand that forms a stable complex with technetium‑99m. After intravenous injection, the Tc‑99m‑exametazime complex crosses the blood‑brain barrier and distributes proportionally to regional cerebral blood flow, allowing single‑photon emission computed tomography (SPECT) to generate perfusion images of brain tissue.

Side Effects

Medi-Exametazim may cause adverse reactions following intravenous administration.

Common Side Effects

  • Injection site pain or erythema
  • Mild nausea or vomiting
  • Transient headache
  • Dizziness or light‑headedness
  • Flushing or warmth sensation
  • Temporary hypotension

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Severe hypotension requiring medical intervention
  • Pulmonary edema
  • Cardiac arrhythmias
  • Acute renal impairment
  • Severe skin reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

  • Prior to use, clinicians should evaluate patient history and current condition.
  • Allergy assessment: confirm no known hypersensitivity to technetium‑99m or exametazime.
  • Pregnancy considerations: avoid unless benefits outweigh potential risks.
  • Renal function: assess in patients with impaired kidney function.
  • Concurrent radiopharmaceuticals: avoid overlapping studies that may interfere with imaging.
  • Drug interactions: review concomitant medications that could affect hemodynamics.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Exametazime may interact with other agents that influence radiotracer distribution or cardiovascular stability.

Major Interactions (Avoid)

  • Other technetium‑99m labeled agents: competition for binding sites.
  • Strong reducing agents: may destabilise the Tc‑99m complex.
  • High‑dose iodine compounds: can alter biodistribution.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypotensive responses.
  • Sedatives or anxiolytics: can increase dizziness or fainting risk.
  • Iodinated contrast media: may affect image quality if administered close in time.

Frequently Asked Questions

Medi-Exametazim is a radiopharmaceutical used to assess cerebral blood flow during single‑photon emission computed tomography (SPECT). It helps clinicians evaluate brain perfusion in conditions such as acute stroke, epilepsy and dementia, providing functional imaging that complements structural studies.

Exametazime chelates technetium‑99m to form a stable complex that, after intravenous injection, crosses the blood‑brain barrier. The complex distributes in proportion to regional cerebral blood flow, allowing SPECT cameras to detect gamma emissions and generate detailed perfusion maps of the brain.

The administered activity of Medi-Exametazim is determined by the prescribing physician or nuclear medicine specialist based on patient weight, the specific imaging protocol and regulatory guidelines. Dosage is individualized and should follow the local radiopharmacy’s preparation standards.

Safety data for exametazime in pregnancy and lactation are limited. It should only be used when the potential diagnostic benefit outweighs any possible risk to the fetus or infant. Clinicians should discuss alternatives and obtain informed consent before administration.

To place an order, submit an enquiry on the Medi-Exametazim product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Medi-Exametazim (exametazime) is a technetium‑99m based tracer, offering high image quality, a relatively short half‑life and widespread availability of Tc‑99m generators. Compared with iodine‑123 or fluorine‑18 agents, it provides lower radiation dose and can be prepared on‑site, though image resolution may be slightly lower than PET tracers.

The product must be stored refrigerated at 2‑8 °C, protected from light, and kept in its original container. It should not be frozen or shaken, and any unused portion should be discarded according to local radiopharmaceutical waste regulations.

Medi-Exametazim is supplied as a sterile injection solution for intravenous use. It is administered by a qualified healthcare professional, typically as a single bolus injection, followed by a waiting period to allow tracer distribution before SPECT imaging commences.

Serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, pulmonary edema, and cardiac arrhythmias. Immediate medical attention is required if any of these events occur. Patients should be monitored closely during and after injection.

Medi-Exametazim is contraindicated in individuals with known hypersensitivity to exametazime, technetium‑99m or any component of the formulation. It should also be avoided in patients with unstable cardiovascular status or severe renal impairment unless the diagnostic benefit justifies use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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