Product image of Medi-Macro (Human Albumin As Macroaggregates) supplied by GNH India

Medi-Macro

Active Ingredient:
Human Albumin As Macroaggregates
Origin:
EU

Medi-Macro (Human Albumin As Macroaggregates)

Human Albumin As Macroaggregates, the active ingredient in Medi-Macro, is a Biologic presented as a solution for injection for intravenous use. It is employed as a tracer in lung perfusion imaging, primarily for adult patients undergoing ventilation/perfusion (V/Q) scans to assess pulmonary blood flow.

GNH India supplies Medi-Macro as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides cold‑chain logistics for biologic injectables. Customers receive regulatory documentation and support for import clearance.

Manufacturer / TM Owner

Medi-Radiopharma Kft.

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Indications & Clinical Uses

Medi-Macro is used in nuclear medicine for pulmonary perfusion assessment.

  • Lung perfusion imaging: provides quantitative assessment of regional pulmonary blood flow.
  • Ventilation/perfusion (V/Q) scan: enables detection of pulmonary embolism by comparing ventilation and perfusion patterns.
  • Pre‑operative evaluation: assists in evaluating lung function before thoracic surgery.

How It Works

  • After intravenous injection, the particulate albumin macroaggregates travel through the bloodstream and become lodged in the small capillaries of the pulmonary circulation. Their size and composition create a localized radiopaque signal that can be captured by gamma cameras, allowing clinicians to visualize and quantify regional lung perfusion during imaging studies.

Side Effects

Common Side Effects

  • Transient dyspnea: short‑lasting shortness of breath after injection.
  • Chest discomfort: mild pain or pressure in the chest area.
  • Mild fever: low‑grade temperature elevation.
  • Injection site erythema: redness at the site of administration.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Pulmonary embolism: macroaggregate lodging causing a perfusion defect.
  • Severe hypotension: marked drop in blood pressure following administration.

Precautions & Warnings

Prior to administration, consider the following precautions:

  • Allergy assessment: verify no known hypersensitivity to human albumin.
  • Patient condition: ensure appropriate indication and assess pulmonary status.
  • Aseptic technique: maintain sterility during preparation and injection.
  • Monitoring: observe vital signs during and after injection for adverse reactions.
  • Contraindication: avoid use in patients with severe pulmonary hypertension.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Medi-Macro may interact with other agents used in diagnostic imaging or affecting pulmonary circulation.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals: may interfere with image interpretation.
  • High‑dose anticoagulants: can alter macroaggregate distribution.
  • Severe anemia: may affect tracer uptake and imaging quality.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may modify heart rate monitoring during scans.
  • Diuretics: can change pulmonary capillary pressure and affect distribution.
  • Iodinated contrast agents: may impact subsequent nuclear imaging results.

Frequently Asked Questions

Medi-Macro is a diagnostic radiopharmaceutical used as a tracer in lung perfusion imaging, particularly for ventilation/perfusion (V/Q) scans that help detect pulmonary embolism and assess regional blood flow in the lungs.

Human Albumin As Macroaggregates consist of tiny albumin particles that, after intravenous injection, become trapped in the pulmonary capillaries. Their radioactivity creates a detectable signal on gamma cameras, allowing clinicians to map lung perfusion patterns.

The dose of Medi-Macro is determined by the prescribing physician or nuclear medicine specialist based on the specific imaging protocol, patient characteristics, and the required radiotracer activity. No fixed dosing regimen is provided here.

Safety data for Medi-Macro in pregnancy and lactation are limited. The product should only be used if the potential diagnostic benefit outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Medi-Macro, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling) and necessary import documentation.

Medi-Macro uses human albumin macroaggregates, which are widely accepted for their predictable pulmonary capillary lodging and high imaging quality. Alternative agents may use different protein carriers or particle sizes, but the clinical performance of Medi-Macro is comparable to other FDA‑ or EMA‑approved perfusion tracers.

Medi-Macro must be stored at 2‑8 °C in its original packaging, protected from light. It should not be frozen or shaken, and any unused portion should be discarded according to local regulations after the recommended storage period.

Medi-Macro is supplied as a sterile solution for injection and is administered intravenously by a qualified healthcare professional. The injection is performed under aseptic conditions, typically as a rapid bolus, followed by immediate imaging.

The most serious risks include anaphylactic reactions, pulmonary embolism due to macroaggregate lodging, and severe hypotension. Patients should be monitored closely during and after administration, and emergency measures should be readily available.

Medi-Macro should not be used in individuals with known hypersensitivity to human albumin, severe pulmonary hypertension, or those for whom the diagnostic benefit does not outweigh the potential risks. The decision must be made by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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