Product image of Medialipide (Soya-Bean Oil Refined, Triglycerides, Medium Chain) supplied by GNH India

Medialipide

Active Ingredient:
Soya-Bean Oil Refined, Triglycerides, Medium Chain
Origin:
EU

Medialipide (Soya-Bean Oil Refined, Triglycerides, Medium Chain)

Soya-Bean Oil Refined, Medium Chain Triglycerides, the active ingredient in Medialipide, is an excipient presented as an intravenous solution for intravenous use. It provides a source of medium-chain fatty acids and serves as a lipid carrier in parenteral formulations.

GNH India supplies Medialipide as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

B.Braun Medical Sas

1
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Indications & Clinical Uses

  • Medialipide, containing medium-chain triglycerides, is used as a lipid component in intravenous nutrition and drug delivery systems.
  • Parenteral nutrition: supplies calories and essential fatty acids for patients requiring intravenous feeding.
  • Lipid-based drug formulations: acts as a solubilizing vehicle for fat‑soluble medications administered intravenously.
  • Organ transplantation support: provides an energy substrate in post‑operative IV regimens.

How It Works

  • Medium-chain triglycerides in Medialipide are hydrolyzed by plasma lipases to medium-chain fatty acids, which are rapidly taken up by the liver and oxidized for energy. The resulting fatty acids also integrate into lipid micelles, enhancing the solubility and stability of co‑administered lipophilic drugs, thereby facilitating their intravenous delivery.

Side Effects

Medialipide may be associated with several adverse reactions when administered intravenously.

Common Side Effects

  • Hypertriglyceridemia: mild elevation of serum triglyceride levels.
  • Infusion site reactions: erythema, warmth, or mild pain at the catheter site.
  • Transient fever: low‑grade temperature rise during infusion.
  • Nausea or mild gastrointestinal discomfort.
  • Headache: occasional mild headache during or after infusion.
  • Allergic rash: skin erythema or urticaria.

Serious or Rare Side Effects

  • Anaphylaxis: severe hypersensitivity requiring immediate medical intervention.
  • Fat overload syndrome: accumulation of lipids leading to organ dysfunction.
  • Hepatic dysfunction: elevated liver enzymes or hepatic steatosis.
  • Acute pancreatitis: inflammation of the pancreas.
  • Embolism: lipid emboli causing respiratory or circulatory compromise.
  • Severe hypotension: sudden drop in blood pressure during infusion.

Precautions & Warnings

  • When using Medialipide, clinicians should observe specific safety measures.
  • Patient assessment: evaluate lipid tolerance and baseline triglyceride levels.
  • Monitoring: check serum triglycerides and liver enzymes during therapy.
  • Allergy screening: assess for soy or lipid emulsion hypersensitivity.
  • Dose adjustment: modify in patients with impaired fatty acid oxidation.
  • Compatibility: verify compatibility with co‑administered drugs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Medialipide can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Propofol: additive lipid load may cause fat overload.
  • Corticosteroids: can increase triglyceride concentrations.
  • Heparin: may potentiate hypertriglyceridemia.

Moderate Interactions (Monitor Closely)

  • Vincristine: lipid emulsion may alter drug distribution.
  • Cyclosporine: monitor liver function due to combined hepatic load.
  • Statins: watch for additive hepatic effects.

Frequently Asked Questions

Medialipide is an intravenous lipid excipient containing refined soy‑bean oil and medium‑chain triglycerides. It is employed as a source of calories and essential fatty acids in parenteral nutrition and as a solubilizing carrier for lipophilic drugs administered by infusion.

The medium‑chain triglycerides are hydrolyzed by circulating lipases to medium‑chain fatty acids, which are rapidly oxidized for energy. These fatty acids also form micellar structures that improve the solubility and stability of co‑administered lipophilic compounds during intravenous delivery.

The dosing of Medialipide is determined by the prescribing clinician based on the patient’s nutritional needs, lipid tolerance, and the specific therapeutic protocol. No fixed regimen is provided; the prescriber sets the appropriate volume and rate of infusion.

Safety data for Medialipide in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against any theoretical risks and consider alternative nutrition strategies if safer options are available.

To request Medialipide, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Compared with long‑chain triglyceride emulsions, Medialipide’s medium‑chain profile is metabolized more rapidly, offering quicker energy delivery and reduced risk of lipid accumulation. It may be preferred when a faster‑acting lipid source or enhanced solubilization of lipophilic drugs is required.

Medialipide should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or vigorously shake the solution, as this can compromise emulsion stability.

Medialipide is administered intravenously, either as a continuous infusion for nutritional support or as a bolus when used as a drug‑solubilizing carrier. Administration should follow aseptic technique and be compatible with the infusion equipment used.

Serious risks include anaphylactic reactions, fat overload syndrome, hepatic dysfunction, acute pancreatitis, lipid embolism, and severe hypotension. Prompt recognition and management of these events are essential during infusion.

Patients with known hypersensitivity to soy products, severe hypertriglyceridemia, impaired fatty‑acid oxidation disorders, or those who have experienced previous lipid‑emulsion reactions should avoid Medialipide unless a risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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