Product image of Medifolin (Calcium Folinate) supplied by GNH India

Medifolin

Active Ingredient:
Calcium Folinate
Origin:
EU

Medifolin (Calcium Folinate)

Calcium Folinate, the active ingredient in Medifolin, is a folate analog presented as an oral formulation for oral use. It is employed to mitigate toxicity from certain chemotherapy agents and to supplement folate in deficiency states. It is commonly used in oncology protocols and in patients requiring folate repletion before or after antifolate therapy.

GNH India supplies Medifolin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support import and clinical use.

Manufacturer / TM Owner

Laboratório Medinfar - Produtos Farmacêuticos, S.A.

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Indications & Clinical Uses

Calcium Folinate is used in clinical settings that involve antifolate chemotherapy or folate deficiency.

  • Methotrexate toxicity rescue: reduces high‑dose methotrexate‑induced bone marrow and renal toxicity.
  • 5‑Fluorouracil modulation: enhances the anticancer effect of 5‑FU in colorectal and head‑neck cancers.
  • Folate deficiency supplementation: restores normal folate levels in patients with folate‑deficient states.

How It Works

  • Calcium Folinate is a reduced, biologically active form of folic acid that bypasses the dihydrofolate reductase step, directly replenishing intracellular tetrahydrofolate pools. By restoring folate co‑factor availability, it supports nucleotide synthesis and DNA repair, counteracting the inhibition caused by antifolate agents such as methotrexate, and potentiates the binding of fluoropyrimidines to thymidylate synthase, enhancing their cytotoxic activity. This dual action helps protect normal cells while improving therapeutic outcomes.

Side Effects

Calcium Folinate may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Vomiting: occasional episodes.
  • Diarrhea: loose stools.
  • Transient rash: mild skin irritation.
  • Elevated liver enzymes: mild hepatic enzyme rise.
  • Fever: low‑grade temperature increase.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hepatic dysfunction: marked increase in transaminases or jaundice.
  • Neutropenia: significant reduction in white blood cells.
  • Thromboembolic events: rare clot formation.
  • Renal failure: acute kidney injury in predisposed patients.
  • Hypersensitivity syndrome: multi‑system allergic response.

Precautions & Warnings

When prescribing Calcium Folinate, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal impairment: monitor kidney function and adjust therapy as needed.
  • Hepatic dysfunction: assess liver enzymes before and during treatment.
  • Pregnancy and lactation: evaluate risk‑benefit ratio and consult obstetric guidance.
  • Concomitant antifolates: avoid simultaneous use that may diminish rescue effect.
  • Known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Calcium Folinate can interact with other medicines, influencing efficacy or toxicity.

Major Interactions (Avoid)

  • Pemetrexed: concurrent use may increase toxicity and reduce rescue efficacy.
  • High‑dose methotrexate without appropriate timing: may negate protective effect.
  • Anticoagulants (warfarin): folate may alter INR, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • 5‑Fluorouracil: may enhance cytotoxicity, necessitate dose adjustment.
  • Cytarabine: potential additive myelosuppression.
  • Trimethoprim‑sulfamethoxazole: may increase risk of bone marrow suppression.

Frequently Asked Questions

Medifolin contains calcium folinate, which is employed to reduce toxicity from high‑dose methotrexate, to enhance the anticancer activity of 5‑fluorouracil, and to correct folate deficiency in patients who require supplemental folate for metabolic or therapeutic reasons.

Calcium folinate is a reduced form of folic acid that bypasses the dihydrofolate reductase step, directly replenishing intracellular tetrahydrofolate pools. This restores folate‑dependent enzymatic reactions, supports DNA synthesis, and counteracts the inhibition caused by antifolate drugs while also potentiating fluoropyrimidine activity.

The dose of Medifolin is determined by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and other individual factors. No fixed regimen is provided here; the prescriber will set the appropriate dosage.

Safety data for calcium folinate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To order Medifolin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Medifolin (calcium folinate) is a biologically active folate that bypasses the dihydrofolate reductase step, unlike folic acid which requires conversion. This makes it more effective for rescue from antifolate chemotherapy and for enhancing fluoropyrimidine activity, whereas simple folic acid does not provide the same rapid intracellular folate replenishment.

Medifolin should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in extreme heat or humidity.

Medifolin is administered orally. The tablet or capsule should be swallowed whole with a glass of water, unless otherwise directed by a healthcare professional. It may be taken with or without food, depending on the prescribing physician’s instructions.

Serious risks include anaphylactic reactions, severe hepatic dysfunction (marked transaminase elevation or jaundice), acute renal failure, and rare cases of neutropenia or hypersensitivity syndrome. Patients should be monitored for signs of these events, and treatment should be discontinued if they occur.

Medifolin should be avoided in individuals with known hypersensitivity to calcium folinate or any of its excipients, and in patients with severe renal or hepatic impairment unless closely monitored. It is also contraindicated when used concurrently with certain antifolate agents that may negate its protective effect.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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