Medispray (Chlorhexidine Gluconate, Lidocaine Hydrochloride)

Medispray, containing chlorhexidine and lidocaine, is used for oral mucosal antisepsis and analgesia.

• Aphthous ulcers: reduces bacterial load and eases pain associated with ulcerative lesions.
• Post‑operative oral care: helps prevent infection and provides local anesthesia after dental extractions or surgeries.
• Oral mucositis: diminishes microbial colonisation and alleviates discomfort during chemotherapy or radiotherapy.
• Dental procedures: prepares the oral cavity by disinfecting and numbing the site before operative work.
• General mouth sores: offers rapid pain relief and antiseptic protection for traumatic or inflammatory lesions.

• Chlorhexidine gluconate disrupts bacterial cell membranes by binding to phospholipids, causing leakage of intracellular contents and cell death. Lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, preventing depolarisation and providing local anaesthesia. The combined action yields antimicrobial activity together with rapid topical pain relief on the oral mucosa.

Medispray may cause several adverse reactions, most of which are mild and transient.

Common Side Effects

• Altered taste sensation: temporary metallic or bitter taste.
• Mild burning or stinging: brief discomfort at the application site.
• Transient numbness: short‑lasting loss of sensation in the treated area.
• Oral irritation: mild redness or soreness.
• Localised allergic contact dermatitis: redness and itching limited to the spray area.

Serious or Rare Side Effects

• Anaphylactic reaction: severe systemic allergy requiring immediate medical attention.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare severe skin reactions.
• Extensive mucosal ulceration: worsening of oral lesions beyond expected irritation.
• Systemic lidocaine toxicity: rare, may present with dizziness, tinnitus, or cardiac effects.
• Severe hypersensitivity: swelling of lips, tongue, or throat.

Before using Medispray, consider the following safety measures.

• Known hypersensitivity: avoid if the patient has documented allergy to chlorhexidine or lidocaine.
• Damaged mucosa: do not apply to extensive ulcerations or open wounds beyond intended area.
• Duration of use: limit application to the period recommended by a healthcare professional.
• Persistent lesions: seek medical advice if oral lesions do not improve within 7 days.
• Interaction with other oral antiseptics: avoid simultaneous use of multiple chlorhexidine products.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Medispray can interact with other agents; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

• Concurrent topical anesthetics: may increase systemic lidocaine exposure.
• Multiple chlorhexidine products: additive irritation or mucosal toxicity.

Moderate Interactions (Monitor Closely)

• Systemic local anesthetics: monitor cumulative lidocaine dose.
• Alcohol‑based mouthwashes: may heighten oral irritation.
• Anticoagulants: increased bleeding risk if mucosal integrity is compromised.
• Antifungal agents: potential for altered oral flora balance.
• Salicylate‑containing oral gels: monitor for enhanced local irritation.