Medoclor (Cefaclor)

• Cefaclor is used to treat bacterial infections affecting the respiratory, ear, throat and skin systems.
• Upper respiratory tract infections: reduces bacterial load and alleviates symptoms such as cough and sore throat.
• Acute otitis media: eliminates the causative organisms in middle‑ear infections.
• Pharyngitis: clears streptococcal and other bacterial causes of sore throat.
• Skin and soft‑tissue infections: resolves cellulitis, impetigo and other bacterial skin conditions.

• Cefaclor inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, which disrupts the cross‑linking of peptidoglycan strands. This leads to weakened cell walls and eventual bacterial lysis, particularly against gram‑positive and some gram‑negative organisms.

Cefaclor may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Diarrhea: loose stools, sometimes watery.
• Abdominal pain: cramping or discomfort.
• Vomiting: occasional emesis.
• Headache: transient mild headache.
• Rash: mild skin redness or itching.

Serious or Rare Side Effects

• Clostridioides difficile‑associated diarrhea: severe colitis.
• Anaphylaxis: life‑threatening allergic reaction.
• Stevens‑Johnson syndrome: severe skin blistering.
• Serum sickness: fever, joint pain, rash.
• Hemolytic anemia: breakdown of red blood cells.
• Liver enzyme elevations: signs of hepatic stress.

• Before prescribing Cefaclor, clinicians should consider several safety factors.
• Renal function assessment: adjust dose in patients with impaired kidney function.
• Penicillin allergy caution: avoid in patients with known hypersensitivity to β‑lactams.
• Superinfection monitoring: watch for secondary infections such as fungal overgrowth.
• Hypersensitivity history: discontinue if rash or allergic signs develop.
• Medical supervision: use only under physician direction.
• Store at below 25°C: keep in the original pack, protect from moisture.

Cefaclor can affect or be affected by other medicines; interactions vary in severity.

Major Interactions (Avoid)

• Probenecid: reduces renal excretion, increasing cefaclor levels.
• Anticoagulants (e.g., warfarin): may enhance anticoagulant effect and raise INR.
• Live vaccines: diminished vaccine efficacy and increased infection risk.

Moderate Interactions (Monitor Closely)

• Oral contraceptives: possible reduction in contraceptive effectiveness.
• Metformin: elevated plasma concentrations in renal impairment.
• Aminoglycosides: additive nephrotoxicity when combined.