Product image of Medotramol (Tramadol Hydrochloride, Paracetamol) supplied by GNH India

Medotramol

Active Ingredient:
Tramadol Hydrochloride, Paracetamol
Origin:
EU

Medotramol (Tramadol Hydrochloride, Paracetamol)

Tramadol Hydrochloride and Paracetamol, the active ingredients in Medotramol, are analgesics presented as an oral tablet for oral use. They provide pain relief for moderate to severe acute and chronic pain in adult patients, combining opioid‑type activity with central COX inhibition.
GNH India supplies Medotramol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Medotramol is indicated for pain management across several clinical settings.

  • Acute postoperative pain: reduces pain intensity after surgical procedures.
  • Musculoskeletal pain: alleviates pain from injuries or inflammatory conditions.
  • Cancer‑related pain: provides supplemental relief for breakthrough pain in oncology patients.

How It Works

  • Tramadol Hydrochloride acts as a weak mu‑opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain inhibition. Paracetamol contributes analgesia primarily through central cyclooxygenase inhibition, reducing prostaglandin synthesis in the CNS. The combined actions produce additive pain relief without significant anti‑inflammatory effects.

Side Effects

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Dizziness: transient light‑headedness.
  • Constipation: reduced bowel movements.
  • Headache: occasional throbbing pain.
  • Somnolence: feeling unusually sleepy.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Seizures: risk increased at high doses or with interacting drugs.
  • Respiratory depression: slowed breathing, especially with CNS depressants.
  • Allergic reactions: rash, itching, or swelling.
  • Serotonin syndrome: agitation, hyperthermia, or tremor when combined with serotonergic agents.
  • Hepatotoxicity: rare liver injury with prolonged use.

Precautions & Warnings

When prescribing Medotramol, consider the following precautions.

  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Hepatic function evaluation: monitor liver enzymes in patients with liver disease.
  • Seizure history: use cautiously in individuals with a history of seizures.
  • Concomitant CNS depressants: avoid or reduce dose when combined with alcohol, benzodiazepines, or other sedatives.
  • Serotonin syndrome risk: review concurrent serotonergic medications.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Medotramol may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe serotonin syndrome.
  • SSRIs/SNRIs: increased serotonin toxicity.
  • Alcohol or other CNS depressants: enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Warfarin: possible alteration of anticoagulant effect.
  • CYP2D6 inhibitors (e.g., fluoxetine): may increase tramadol plasma levels.

Frequently Asked Questions

Medotramol is a prescription oral tablet that combines tramadol hydrochloride and paracetamol to provide analgesic relief for moderate to severe pain, such as postoperative discomfort, musculoskeletal injuries, and breakthrough cancer pain.

Tramadol hydrochloride binds weakly to mu‑opioid receptors and blocks the reuptake of norepinephrine and serotonin, enhancing the body’s natural pain‑inhibiting pathways while also modulating central neurotransmitter activity.

The specific dose and dosing schedule of Medotramol are determined by the prescribing clinician based on the patient’s pain severity, medical history, and response to therapy. No fixed regimen is provided here.

Safety data for Medotramol in pregnancy and lactation are limited. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the Medotramol product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑ingredient opioids, Medotramol offers combined opioid and non‑opioid mechanisms, potentially allowing lower opioid doses for similar analgesia. It differs from NSAIDs by lacking anti‑inflammatory activity and from pure acetaminophen by adding opioid‑type effects.

Medotramol tablets should be stored at room temperature, below 25 °C, in the original container, protected from moisture and direct sunlight to maintain stability.

Medotramol is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed unless specifically directed by a healthcare professional.

Serious risks include respiratory depression, seizures, serotonin syndrome when combined with serotonergic drugs, and rare allergic reactions such as rash or anaphylaxis. Patients should be monitored for these events, especially when using other CNS depressants.

Medotramol is contraindicated in individuals with known hypersensitivity to tramadol, paracetamol, or any excipients, as well as in patients taking monoamine oxidase inhibitors, or those with uncontrolled severe respiratory depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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