Product image of Medovir (Aciclovir) supplied by GNH India

Medovir

Active Ingredient:
Aciclovir
Origin:
EU

Medovir (Aciclovir)

Aciclovir, the active ingredient in Medovir, is an antiviral presented as a topical formulation for cutaneous use. It treats herpes virus infections of the skin and mucous membranes in adults and children.

GNH India supplies Medovir as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Aciclovir topical therapy is used to manage infections caused by herpes viruses affecting the skin and mucous membranes.

  • Herpes labialis: reduces lesion duration and pain when applied at the first sign of an outbreak.
  • Genital herpes: alleviates symptoms and promotes faster healing of genital lesions.
  • Herpes zoster (topical treatment): provides local antiviral activity to lessen skin lesions and discomfort.

How It Works

  • Aciclovir is a nucleoside analogue that, after intracellular phosphorylation, competitively inhibits viral DNA polymerase. This blocks the synthesis of viral DNA, preventing replication of herpes simplex and varicella‑zoster viruses in infected cells, thereby limiting lesion development.

Side Effects

Topical aciclovir may cause local skin reactions, ranging from mild irritation to rare severe hypersensitivity.

Common Side Effects

  • Burning sensation at the application site.
  • Stinging or itching.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Mild rash.
  • Local tenderness.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Ocular irritation if applied near the eye.
  • Systemic absorption leading to renal toxicity (rare).
  • Anaphylactic reaction.
  • Unexplained fever with rash.

Precautions & Warnings

Before using Medovir, consider the following precautions to ensure safe and effective treatment.

  • Assess renal function: adjust use if significant renal impairment is present.
  • Avoid extensive damaged skin: limit application to small, intact lesions.
  • Do not apply near eyes or mucous membranes: risk of irritation.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Aciclovir can interact with other medicines, affecting its concentration or the safety of co‑administered drugs.

Major Interactions (Avoid)

  • Probenecid: reduces renal clearance, increasing aciclovir plasma levels.
  • Didanosine: may enhance didanosine toxicity.
  • Nephrotoxic agents (e.g., aminoglycosides): combined use can worsen renal function.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may increase aciclovir levels modestly.
  • NSAIDs: monitor renal function when used together.
  • Other antivirals (e.g., valacyclovir): assess cumulative antiviral effect.
  • Immunosuppressants: watch for altered infection risk.

Frequently Asked Questions

Medovir is a topical formulation of aciclovir that is used to treat skin and mucous‑membrane infections caused by herpes viruses, including cold sores (herpes labialis), genital herpes lesions, and the skin manifestations of herpes zoster when applied directly to the affected area.

Aciclovir is a nucleoside analogue that is taken up by infected cells and phosphorylated to its active triphosphate form. This active metabolite competitively inhibits viral DNA polymerase, halting viral DNA synthesis and preventing replication of herpes simplex and varicella‑zoster viruses.

The dosage and frequency of Medovir are determined by the prescribing healthcare professional based on the specific indication, severity of the outbreak, patient age, and renal function. Patients should follow the prescriber’s instructions and the product label precisely.

Safety data for topical aciclovir in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any theoretical risks. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their physician before starting treatment.

To order Medovir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Medovir (aciclovir) and other topical antivirals such as penciclovir have similar mechanisms of inhibiting viral DNA synthesis. Aciclovir is well‑studied, widely available, and generally effective when applied early. Some clinicians prefer penciclovir for its longer intracellular half‑life, but clinical outcomes are comparable for most herpes lesions.

Medovir should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Follow any additional handling instructions provided on the label to maintain product stability.

Medovir is applied directly to the affected skin area. The prescribed amount is spread in a thin layer using clean hands, typically five times daily for the first few days of an outbreak, then reduced as directed by the prescriber. Hands should be washed before and after application.

Serious risks, although rare, include severe allergic reactions such as Stevens‑Johnson syndrome, anaphylaxis, and ocular irritation if the product contacts the eye. Systemic absorption can lead to renal toxicity, especially in patients with pre‑existing kidney impairment. Immediate medical attention is required if any severe reaction occurs.

Medovir should be avoided in individuals with known hypersensitivity to aciclovir or any of the excipients, in patients with severe renal impairment unless dose‑adjusted by a physician, and in anyone with extensive broken skin or open wounds at the intended application site.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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