Product image of Medovir (Aciclovir) supplied by GNH India

Medovir

Active Ingredient:
Aciclovir
Origin:
EU

Medovir (Aciclovir)

Aciclovir, the active ingredient in Medovir, is an antiviral presented as an intravenous solution for IV use. It treats infections caused by herpes viruses, including herpes simplex, varicella‑zoster, and herpes encephalitis, in adult and pediatric patients as prescribed.

GNH India supplies Medovir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Customers benefit from reliable logistics, comprehensive documentation, and responsive technical support throughout the supply chain.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

  • Aciclovir is an antiviral that targets herpesvirus infections.
  • Herpes simplex virus infections: reduces lesion formation and accelerates healing of oral and genital sores.
  • Varicella‑zoster virus infections (shingles): alleviates pain and hastens rash resolution.
  • Herpes encephalitis: limits viral replication in the central nervous system, improving survival outcomes.

How It Works

  • Aciclovir is a nucleoside analogue that, after intracellular phosphorylation by viral thymidine kinase, is converted to aciclovir triphosphate. This active metabolite competitively inhibits viral DNA polymerase, causing premature chain termination during viral DNA synthesis. Because phosphorylation occurs preferentially in infected cells, the drug selectively targets replicating herpesviruses while sparing host DNA processes.

Side Effects

Intravenous aciclovir may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fever
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Acute renal failure
  • Seizures
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)

Precautions & Warnings

  • When using Medovir, clinicians should observe several safety measures.
  • Renal function: assess baseline creatinine and adjust dose in impairment.
  • Hydration: ensure adequate fluid intake to reduce nephrotoxicity risk.
  • Concomitant nephrotoxic drugs: avoid or monitor when used with aminoglycosides, vancomycin, or NSAIDs.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Aciclovir can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Probenecid: decreases renal clearance, increasing aciclovir plasma levels.
  • Cidofovir: additive nephrotoxicity when co‑administered.
  • Other nephrotoxic agents (e.g., aminoglycosides, vancomycin): heightened risk of renal injury.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may impair renal function, requiring monitoring.
  • Loop diuretics: can exacerbate renal stress.
  • Warfarin: occasional alterations in INR, monitor coagulation.

Frequently Asked Questions

Medovir contains aciclovir and is used to treat infections caused by herpes viruses. It is indicated for herpes simplex virus infections, varicella‑zoster virus (shingles) infections, and herpes encephalitis, helping to reduce viral replication and improve clinical outcomes in these conditions.

Aciclovir is a nucleoside analogue that is phosphorylated inside infected cells by viral thymidine kinase. The resulting triphosphate form competitively inhibits viral DNA polymerase, causing premature termination of viral DNA chains and thereby halting viral replication while sparing uninfected cells.

The dosage of Medovir is determined by the prescribing clinician based on the specific indication, patient age, weight, renal function, and severity of infection. Healthcare professionals adjust the infusion rate and total daily amount to achieve optimal therapeutic levels while minimizing toxicity.

Safety data for aciclovir in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Medovir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Medovir (intravenous aciclovir) offers rapid plasma concentrations suitable for severe or systemic herpesvirus infections, whereas oral agents like valacyclovir or famciclovir are used for milder cases. Compared with newer antivirals, aciclovir has a well‑established safety profile but may require dose adjustment in renal impairment.

Medovir should be stored at room temperature, below 25 °C, in its original packaging. Keep the solution protected from moisture and direct light. Do not freeze. Before administration, inspect the product for particulate matter and ensure aseptic handling according to standard IV preparation procedures.

Medovir is given by intravenous infusion. The recommended infusion rate and total daily dose are set by the treating physician, who may divide the total amount into multiple infusions per day. Administration should be performed by qualified healthcare personnel using sterile technique.

The most serious adverse events associated with intravenous aciclovir include acute renal failure, seizures, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of nephrotoxicity, neurological changes, and hypersensitivity throughout treatment.

Medovir is contraindicated in individuals with known hypersensitivity to aciclovir or any component of the formulation. Caution is advised for patients with severe renal impairment, as dose adjustment may be required, and for those with a history of severe allergic reactions to antiviral agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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