Product image of Medovir (Aciclovir) supplied by GNH India

Medovir

Active Ingredient:
Aciclovir
Origin:
EU

Medovir (Aciclovir)

Aciclovir, the active ingredient in Medovir, is an antiviral presented as an injection solution for intravenous use. It treats herpes simplex virus infections, varicella‑zoster virus infections and related conditions in patients requiring systemic therapy.

GNH India supplies Medovir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Aciclovir is indicated for viral infections caused by herpes viruses and is administered intravenously for systemic disease control.

  • Herpes simplex virus infections: reduces lesion duration and viral shedding.
  • Varicella‑zoster virus infections (chickenpox): limits disease severity and accelerates recovery.
  • Herpes zoster: alleviates pain and speeds healing of skin lesions.
  • Herpes encephalitis: improves survival rates and neurological outcomes.

How It Works

  • Aciclovir is a nucleoside analogue that is phosphorylated by viral thymidine kinase to its active triphosphate form. The active metabolite competitively inhibits viral DNA polymerase, causing premature chain termination during viral DNA synthesis, thereby preventing replication of herpes simplex and varicella‑zoster viruses.

Side Effects

Common Side Effects

  • Injection site pain: mild discomfort at the infusion site.
  • Fever: transient elevation of body temperature.
  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Vomiting: occasional episodes.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Nephrotoxicity: impaired kidney function, especially with high doses.
  • Thrombocytopenia: reduced platelet count leading to bleeding risk.
  • Severe allergic reactions: anaphylaxis or angioedema.
  • Seizures: rare neurologic events.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.

Precautions & Warnings

Before initiating therapy, consider patient-specific factors and monitor for adverse events.

  • Renal function monitoring: assess creatinine clearance and adjust dose as needed.
  • Hydration status: ensure adequate fluid intake to reduce nephrotoxicity risk.
  • Dose adjustment in renal impairment: modify regimen based on renal function.
  • Hypersensitivity avoidance: discontinue if signs of allergic reaction appear.
  • Pregnancy considerations: safety unknown; use only if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Aciclovir may interact with other medicines that affect renal clearance or increase toxicity.

Major Interactions (Avoid)

  • Probenecid: reduces renal excretion, raising aciclovir plasma levels.
  • Cimetidine: may increase serum concentrations of aciclovir.
  • Concurrent nephrotoxic agents (e.g., aminoglycosides): heightened risk of kidney injury.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can impair renal function, requiring closer monitoring.
  • Valproic acid: may increase risk of neurotoxicity.
  • Immunosuppressants (e.g., cyclosporine): monitor for enhanced infection susceptibility.

Frequently Asked Questions

Medovir is an intravenous formulation of aciclovir used to treat systemic infections caused by herpes simplex virus, varicella‑zoster virus, herpes zoster, and herpes encephalitis. It is prescribed when oral therapy is insufficient or when rapid viral suppression is required.

Aciclovir is a nucleoside analogue that, after activation by viral thymidine kinase, becomes a triphosphate that inhibits viral DNA polymerase. This blocks viral DNA chain elongation, preventing replication of herpes viruses and limiting disease progression.

The specific dose of Medovir is determined by the prescribing clinician based on the infection being treated, patient weight, renal function, and severity of disease. Dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for aciclovir in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any potential risk to the fetus or infant.

To order Medovir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Compared with oral agents such as valacyclovir or famciclovir, Medovir provides rapid, high‑level systemic exposure via intravenous infusion, which is advantageous for severe or disseminated infections. Oral antivirals are convenient for mild disease but may achieve lower plasma concentrations than IV aciclovir.

Medovir must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Prior to use, the solution should be inspected for particulate matter and used within the time frame recommended by the manufacturer after dilution.

Medovir is given by intravenous infusion. The product is typically diluted in an appropriate compatible fluid and infused over a period specified by the prescriber, often ranging from 30 minutes to several hours depending on the indication and patient tolerance.

Serious adverse events include nephrotoxicity, thrombocytopenia, severe allergic reactions such as anaphylaxis, seizures, and hepatic dysfunction. Patients should be monitored for changes in renal function, blood counts, liver enzymes, and any signs of hypersensitivity during therapy.

Medovir is contraindicated in patients with known hypersensitivity to aciclovir or any of the formulation components. Caution is advised for individuals with severe renal impairment, pregnant women when benefits do not outweigh risks, and patients receiving other nephrotoxic medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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