Product image of Medracet (Tramadol Hydrochloride, Paracetamol) supplied by GNH India

Medracet

Active Ingredient:
Tramadol Hydrochloride, Paracetamol
Origin:
EU

Medracet (Tramadol Hydrochloride, Paracetamol)

Tramadol Hydrochloride and Paracetamol, the active ingredients in Medracet, are a combination opioid and non‑opioid analgesic presented as an oral tablet for oral use. It is indicated for the management of moderate to severe acute pain, including postoperative and musculoskeletal pain, in adult patients.
GNH India supplies Medracet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Medracet is used as a combination analgesic to treat pain conditions that involve both nociceptive and neuropathic pathways.

  • Moderate to severe acute pain: provides rapid relief by targeting central pain pathways.
  • Post‑operative pain: helps control pain after surgical procedures, facilitating recovery.
  • Musculoskeletal pain: reduces discomfort associated with injuries, strains, and inflammatory conditions.

How It Works

  • Tramadol Hydrochloride acts as a µ‑opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways. Paracetamol contributes analgesic and antipyretic effects primarily through central inhibition of cyclooxygenase enzymes, reducing prostaglandin synthesis. The combined actions provide synergistic pain relief without significant anti‑inflammatory activity.

Side Effects

Adverse reactions may occur with any analgesic combination and should be monitored.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Dizziness: transient sensation of light‑headedness.
  • Constipation: reduced bowel motility.
  • Headache: mild cranial discomfort.
  • Somnolence: increased sleepiness or fatigue.
  • Sweating: excessive perspiration.

Serious or Rare Side Effects

  • Seizures: risk increases with high doses or interacting drugs.
  • Serotonin syndrome: may develop when combined with serotonergic agents.
  • Respiratory depression: especially in patients with compromised breathing.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity: rare liver injury linked to paracetamol overdose.
  • Anaphylaxis: acute allergic response requiring immediate medical attention.

Precautions & Warnings

Before prescribing Medracet, clinicians should consider patient‑specific factors and monitor for potential risks.

  • Assess renal and hepatic function: adjust use if impairment is present.
  • Avoid in severe respiratory depression: may exacerbate breathing difficulties.
  • Use caution with CNS depressants: concurrent sedatives can increase sedation.
  • Monitor for signs of dependence or misuse: especially with prolonged therapy.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Medracet can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome.
  • Selective serotonin reuptake inhibitors (SSRIs) or SNRIs: may precipitate serotonin toxicity.
  • Alcohol or other CNS depressants: heightened sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): increase tramadol plasma levels.
  • Warfarin: paracetamol may enhance anticoagulant effect.
  • Anticonvulsants (e.g., carbamazepine): may lower tramadol efficacy.

Frequently Asked Questions

Medracet is a prescription oral tablet that combines tramadol hydrochloride and paracetamol to provide analgesia for moderate to severe acute pain, including postoperative pain and musculoskeletal discomfort. It is intended for adult patients who require stronger pain control than non‑opioid analgesics alone.

Tramadol hydrochloride acts as a µ‑opioid receptor agonist and also inhibits the reuptake of norepinephrine and serotonin, which enhances descending inhibitory pathways in the central nervous system. This dual mechanism reduces the perception of pain and increases the overall analgesic effect when combined with paracetamol.

The specific dose of Medracet is determined by the prescribing clinician based on the severity of pain, patient characteristics, and any concomitant medications. Healthcare professionals adjust the regimen to achieve effective pain relief while minimizing the risk of adverse effects.

Medracet is classified as pregnancy category C, indicating that risk cannot be ruled out and it should only be used if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before using this medication.

To place an order, submit an enquiry on the Medracet product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Compared with single‑component analgesics, Medracet offers synergistic pain relief by combining an opioid (tramadol) with a non‑opioid (paracetamol). This can provide greater efficacy at lower individual doses, potentially reducing the incidence of opioid‑related side effects seen with stronger opioids, while still addressing moderate to severe pain.

Medracet should be stored below 25 °C in a dry environment. Keep the tablets in their original packaging to protect them from moisture and light, and ensure they are out of reach of children.

Medracet is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any specific dietary considerations.

Serious risks include respiratory depression, especially in patients with compromised breathing, seizures at high doses or when combined with certain medications, serotonin syndrome when used with serotonergic agents, severe skin reactions such as Stevens‑Johnson syndrome, and potential liver injury from paracetamol overdose.

Medracet is contraindicated in patients with known hypersensitivity to tramadol, paracetamol, or any excipients, in those with severe respiratory depression, acute or severe asthma, and in individuals who have taken monoamine oxidase inhibitors within the past 14 days. It should also be avoided in patients with uncontrolled epilepsy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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