Product image of Medulan (Diclofenac Sodium) supplied by GNH India

Medulan

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Medulan (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Medulan, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for skin application. It is used to relieve pain and reduce inflammation in musculoskeletal conditions and is applied directly to the affected area.
GNH India supplies Medulan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aristo Pharma Sp. Z O.O.

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Indications & Clinical Uses

Diclofenac Sodium is a topical NSAID that acts on inflammatory pathways in the musculoskeletal system.

  • Musculoskeletal pain: alleviates pain and improves function in muscles, tendons and joints.
  • Localized inflammation: reduces swelling and erythema in inflamed tissues.
  • Arthritis: provides symptomatic relief of joint pain and stiffness associated with osteoarthritis and rheumatoid arthritis.

How It Works

  • Diclofenac Sodium inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By limiting prostaglandin production at the site of application, the drug reduces vascular permeability, leukocyte infiltration, and nociceptor sensitization, resulting in localized anti‑inflammatory and analgesic effects.

Side Effects

Topical diclofenac can cause local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: redness, itching or mild burning at the application site.
  • Dryness or peeling of the skin.
  • Pruritus (itching).
  • Localized rash.
  • Sensation of warmth or tingling.

Serious or Rare Side Effects

  • Allergic reactions: urticaria, angioedema, or anaphylaxis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic effects: gastrointestinal ulceration or bleeding, especially with extensive use.
  • Cardiovascular events: increased risk of thrombotic events in susceptible individuals.
  • Hepatic or renal impairment: abnormal liver enzymes or reduced kidney function.

Precautions & Warnings

When using Medulan, consider the following safety measures.

  • Assess skin integrity: avoid application on broken, infected or severely irritated skin.
  • Limit application area: do not exceed the recommended surface area to reduce systemic absorption.
  • Avoid concurrent oral NSAIDs: discuss with a healthcare professional before combining therapies.
  • Monitor patients with liver or kidney disease: use with caution and under medical supervision.
  • Pregnant or breastfeeding women: consult a physician before use.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct heat.

Avoid Interactions

Diclofenac Sodium may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Oral anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Systemic NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): potential for enhanced bleeding risk.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may increase ulceration risk.
  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Lithium: diclofenac may raise lithium serum levels.

Frequently Asked Questions

Medulan contains diclofenac sodium and is applied topically to relieve pain and inflammation associated with musculoskeletal pain, localized swelling, and arthritis such as osteoarthritis or rheumatoid arthritis. It targets the affected area directly, providing symptomatic relief without systemic exposure typical of oral NSAIDs.

Diclofenac sodium blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By reducing prostaglandin levels at the site of application, the drug diminishes inflammation, swelling, and pain signals, leading to localized analgesic and anti‑inflammatory effects.

The specific dose and frequency of Medulan are determined by the prescribing healthcare professional based on the severity of the condition, the size of the treatment area, and patient factors. Patients should follow the prescriber’s instructions and the product label carefully.

Safety of topical diclofenac during pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using Medulan to weigh potential risks and benefits.

To request Medulan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with oral NSAIDs, Medulan delivers diclofenac directly to the skin, which can reduce systemic exposure and lower the risk of gastrointestinal side effects. It is similar in efficacy to other topical NSAIDs such as ibuprofen gel, but individual response and tolerability may vary, so clinicians choose based on patient needs and safety profiles.

Medulan should be stored at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Apply a thin layer of Medulan to the clean, dry skin over the affected area, typically 2–4 times daily as directed by a healthcare professional. Gently rub the gel until it is fully absorbed, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis. Systemic absorption can also lead to gastrointestinal bleeding, cardiovascular events, or liver and kidney dysfunction, especially when used over large areas or for prolonged periods.

Medulan should be avoided in individuals with known hypersensitivity to diclofenac or other NSAIDs, those with active skin infections or open wounds at the application site, and patients with a history of severe cardiovascular, gastrointestinal, hepatic, or renal disease unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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