Product image of Mefac (Mefenamic Acid) supplied by GNH India

Mefac

Active Ingredient:
Mefenamic Acid
Origin:
EU

Mefac (Mefenamic Acid)

Mefenamic Acid, the active ingredient in Mefac, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It is indicated for mild to moderate pain, dysmenorrhea and inflammatory musculoskeletal conditions in adult patients.

GNH India supplies Mefac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rowa Pharmaceuticals Limited

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Indications & Clinical Uses

Mefac, an NSAID, is employed to manage pain and inflammation across several clinical settings.

  • Dysmenorrhea: provides relief from menstrual cramps and associated pelvic pain.
  • Musculoskeletal pain: reduces discomfort from strains, sprains and overuse injuries.
  • Mild to moderate pain: alleviates headache, dental pain and postoperative discomfort.
  • Inflammatory conditions: helps control swelling and pain in arthritis and other inflammatory disorders.

How It Works

  • Mefenamic Acid exerts its effect by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin levels leads to diminished peripheral sensitisation and alleviation of inflammatory symptoms.

Side Effects

Mefac may cause a range of adverse reactions, from mild to severe, depending on individual susceptibility.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or pruritus.
  • Diarrhoea or constipation.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe hepatic injury.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylactic or anaphylactoid reactions.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

Before prescribing Mefac, clinicians should consider several safety measures.

  • Renal function assessment: evaluate baseline kidney status, especially in elderly patients.
  • Gastrointestinal risk: avoid in individuals with a history of peptic ulcer disease or bleeding.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Anticoagulant use: monitor closely when combined with warfarin or other blood thinners.
  • Elderly patients: use the lowest effective dose and limit treatment duration.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Mefac can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Lithium: elevated lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal perfusion.
  • Corticosteroids: additive risk of ulceration.
  • SSRIs or SNRIs: enhanced bleeding tendency.
  • ACE inhibitors or ARBs: potential for reduced renal function.
  • Oral hypoglycemics: may affect blood glucose control.

Frequently Asked Questions

Mefac contains mefenamic acid, an NSAID that is commonly prescribed for mild to moderate pain, menstrual cramps (dysmenorrhea), musculoskeletal aches such as sprains or strains, and other inflammatory conditions like arthritis. It works by reducing inflammation and pain at the site of injury or irritation.

Mefenamic acid blocks the activity of cyclooxygenase enzymes (COX‑1 and COX‑2), which are essential for producing prostaglandins. Prostaglandins promote inflammation, pain, and fever, so their reduction leads to decreased swelling, lower pain perception, and antipyretic effects.

The appropriate dose of Mefac is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for mefenamic acid in pregnancy and lactation are limited. It is generally advised to avoid use during the first trimester and to discuss potential risks with a healthcare provider. Breastfeeding mothers should also seek medical advice before taking the medication.

To request Mefac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mefac (mefenamic acid) is similar to other NSAIDs such as ibuprofen or naproxen in its mechanism of COX inhibition, but it may have a slightly higher risk of gastrointestinal side effects. Choice of NSAID often depends on patient tolerance, specific indication, and physician preference.

Mefac should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Mefac is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with food may reduce stomach irritation. Patients should swallow the tablet whole and not crush or chew it unless directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatic injury, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of bleeding, sudden kidney problems, or severe skin rashes.

Mefac is contraindicated in individuals with known hypersensitivity to mefenamic acid or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and patients who are in the third trimester of pregnancy. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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