Product image of Mefenamic Acid supplied by GNH India

Mefenamic Acid

Active Ingredient:
Mefenamic Acid
Origin:
EU

Mefenamic Acid

Mefenamic Acid, the active ingredient in Mefenamic Acid, is a NSAID presented as an oral tablet for oral use. It provides relief of mild to moderate pain, menstrual cramps, and inflammatory conditions in adult patients.

GNH India supplies Mefenamic Acid as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global distribution. We support regulatory compliance and provide technical documentation as required.

Manufacturer / TM Owner

Lyrus Life Sciences Limited

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Indications & Clinical Uses

Mefenamic Acid is indicated for conditions involving pain and inflammation, acting through inhibition of prostaglandin synthesis.

  • Mild to moderate pain: provides analgesic relief for everyday aches.
  • Menstrual pain (dysmenorrhea): reduces uterine cramping and discomfort.
  • Inflammatory conditions (e.g., arthritis): decreases inflammation and associated pain.

How It Works

  • Mefenamic Acid exerts its therapeutic effect by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which leads to a reduction in the synthesis of prostaglandins that mediate pain, fever, and inflammation. This inhibition diminishes the inflammatory response and alleviates associated symptoms without directly affecting platelet function at therapeutic doses.

Side Effects

Mefenamic Acid may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: occasional upset stomach.
  • Abdominal pain: discomfort in the stomach area.
  • Headache: mild to moderate head pain.
  • Dizziness: feeling light‑headed or unsteady.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: severe stomach or intestinal lesions.
  • Renal impairment: reduced kidney function.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome): extensive rash or blistering.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Blood dyscrasias: abnormal blood cell counts.

Precautions & Warnings

When prescribing Mefenamic Acid, clinicians should consider several precautionary measures to minimize risk.

  • Renal function: monitor in patients with existing kidney disease.
  • Gastrointestinal risk: avoid in individuals with a history of ulcer or bleeding.
  • Cardiovascular health: use cautiously in patients with heart disease.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Drug interactions: review concomitant NSAIDs, anticoagulants, and SSRIs.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mefenamic Acid can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible reduction in renal function.
  • Diuretics: increased risk of renal impairment.
  • Lithium: potential elevation of serum lithium levels.

Frequently Asked Questions

Mefenamic Acid is used to relieve mild to moderate pain, reduce menstrual cramps, and treat inflammatory conditions such as arthritis. It belongs to the non‑steroidal anti‑inflammatory drug (NSAID) class and works by decreasing the production of pain‑inducing chemicals in the body.

Mefenamic Acid works by inhibiting cyclooxygenase (COX) enzymes, which are essential for the formation of prostaglandins. By reducing prostaglandin synthesis, the drug lowers inflammation, pain, and fever associated with various conditions.

The appropriate dose of Mefenamic Acid is determined by a qualified prescriber based on the individual’s medical condition, age, and response to therapy. Patients should follow the specific instructions provided by their healthcare professional and not adjust the dose on their own.

Safety of Mefenamic Acid in pregnancy and lactation has not been established. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their doctor.

To order Mefenamic Acid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and any necessary import documentation.

Mefenamic Acid is similar to other NSAIDs in its mechanism of COX inhibition but is often chosen for its efficacy in treating dysmenorrhea and certain inflammatory pains. Compared with ibuprofen or naproxen, it may have a slightly higher risk of gastrointestinal side effects, so clinicians weigh benefits against individual patient risk profiles.

Mefenamic Acid tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Mefenamic Acid is administered orally, typically as a tablet taken with a full glass of water. It may be taken with or without food, but taking it with food can help reduce gastrointestinal discomfort. Patients should swallow the tablet whole and not crush or chew it.

Serious risks include gastrointestinal bleeding or ulceration, severe kidney impairment, liver dysfunction, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice blood in stool or urine, persistent abdominal pain, yellowing of the skin or eyes, or a widespread rash.

Mefenamic Acid should be avoided by individuals with a known hypersensitivity to the drug or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or significant renal or hepatic impairment. It is also contraindicated in patients taking anticoagulants together with SSRIs or other drugs that increase bleeding risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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