Product image of Meflam (Mefenamic Acid) supplied by GNH India

Meflam

Active Ingredient:
Mefenamic Acid
Origin:
EU

Meflam (Mefenamic Acid)

Mefenamic acid, the active ingredient in Meflam, is a non‑steroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain, menstrual discomfort and inflammation associated with conditions such as arthritis.

GNH India supplies Meflam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

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Indications & Clinical Uses

Meflam, an NSAID, acts on inflammatory pathways to provide analgesic and anti‑inflammatory effects.

  • Mild to moderate pain: provides relief in acute or chronic pain conditions.
  • Dysmenorrhea (menstrual pain): reduces uterine cramping and associated discomfort.
  • Arthritic inflammation: alleviates joint swelling and pain in inflammatory arthritis.

How It Works

  • Mefenamic acid exerts its effect by non‑selectively inhibiting cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins involved in pain, fever and inflammation. This inhibition decreases peripheral sensitisation of nociceptors and limits inflammatory mediator release, producing analgesic and anti‑inflammatory outcomes.

Side Effects

Adverse reactions may occur with any NSAID and vary in frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction or elevated liver enzymes.
  • Anaphylactic or severe allergic reactions.
  • Cardiovascular events such as hypertension or thrombotic episodes.

Precautions & Warnings

Before prescribing Meflam, clinicians should consider patient‑specific risk factors and monitor for potential complications.

  • Assess renal function: adjust use in patients with impaired kidney function.
  • Monitor gastrointestinal risk: avoid in patients with active ulcer disease or a history of GI bleeding.
  • Avoid concurrent anticoagulants: increased bleeding risk.
  • Use caution in elderly: higher susceptibility to adverse effects.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Meflam can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal function when combined.
  • Diuretics: may impair renal clearance of mefenamic acid.

Frequently Asked Questions

Meflam contains mefenamic acid, an NSAID that is commonly prescribed for mild to moderate pain, menstrual cramps (dysmenorrhea) and inflammatory conditions such as arthritis. It works by reducing inflammation and providing analgesic relief in these settings.

Mefenamic acid blocks both COX‑1 and COX‑2 enzymes, which are responsible for producing prostaglandins that mediate pain, fever and inflammation. By lowering prostaglandin levels, the drug diminishes peripheral sensitisation of pain receptors and reduces inflammatory swelling.

The appropriate dose of Meflam is determined by the prescribing clinician based on the patient’s condition, age, weight and overall health. Dosage regimens may differ, so patients should follow the specific instructions provided by their healthcare professional.

Safety of mefenamic acid in pregnancy and lactation has not been fully established. It is generally avoided during the first trimester and used only if the potential benefit outweighs the risk. Breastfeeding mothers should consult their physician before use.

To request Meflam, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Meflam (mefenamic acid) is a non‑selective COX inhibitor similar to ibuprofen or naproxen, but it has a slightly different pharmacokinetic profile and may be preferred for dysmenorrhea. Choice of NSAID depends on efficacy, tolerability, patient comorbidities and physician preference.

Meflam should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency.

Meflam is taken orally, usually with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal irritation. Patients should swallow the tablet whole and not crush or chew it.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, severe skin reactions such as Stevens‑Johnson syndrome, and rare but life‑threatening allergic reactions (anaphylaxis). Patients should seek immediate medical attention if they notice signs of these conditions.

Meflam is contraindicated in individuals with known hypersensitivity to mefenamic acid or other NSAIDs, active gastrointestinal ulcer disease, severe renal or hepatic impairment, and in patients taking anticoagulants where bleeding risk is unacceptable. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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