Product image of Mefoxin (Cefoxitin Sodium) supplied by GNH India

Mefoxin

Active Ingredient:
Cefoxitin Sodium
Origin:
EU

Mefoxin (Cefoxitin Sodium)

Cefoxitin Sodium, the active ingredient in Mefoxin, is a second‑generation cephalosporin presented as an injectable formulation for intramuscular use. It treats a range of bacterial infections in adults and children as directed by a healthcare professional.

GNH India supplies Mefoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

I.B.N. Savio S.R.L.

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Indications & Clinical Uses

Cefoxitin Sodium is used to treat infections caused by susceptible bacteria in several organ systems.

  • Respiratory tract infections: effective against community‑acquired pneumonia and bronchitis.
  • Urinary tract infections: clears uncomplicated UTIs caused by susceptible strains.
  • Skin and soft tissue infections: resolves cellulitis and wound infections.
  • Intra‑abdominal infections: manages peritonitis and postoperative intra‑abdominal infections.
  • Gynecologic infections: treats pelvic inflammatory disease and postoperative gynecologic infections.

How It Works

  • Cefoxitin Sodium exerts its antibacterial activity by binding to penicillin‑binding proteins on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, particularly against Gram‑positive and selected Gram‑negative organisms.

Side Effects

Adverse reactions may occur with intramuscular cefoxitin administration.

Common Side Effects

  • Injection site pain: localized discomfort at the injection site.
  • Diarrhea: mild to moderate loose stools.
  • Nausea: feeling of queasiness.
  • Rash: non‑specific skin eruption.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Clostridioides difficile‑associated diarrhea: severe colitis linked to antibiotic use.
  • Neutropenia: marked reduction in neutrophil count, increasing infection risk.

Precautions & Warnings

Cefoxitin Sodium should be used with caution in specific patient populations.

  • Renal impairment: adjust dose or monitor renal function closely.
  • Hepatic dysfunction: use with caution in patients with liver disease.
  • Allergy history: avoid in patients with known cephalosporin or beta‑lactam allergy.
  • Pregnancy and lactation: safety not established; prescribe only if benefit outweighs risk.
  • Concomitant nephrotoxic drugs: monitor kidney function when used together.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Cefoxitin Sodium may interact with other medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Carbapenems (e.g., imipenem): antagonistic antibacterial effect.
  • Aminoglycosides: increased risk of nephrotoxicity.
  • Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may affect renal clearance of cefoxitin.
  • Oral contraceptives: possible reduction in contraceptive efficacy.
  • Probenecid: may increase cefoxitin plasma concentrations.

Frequently Asked Questions

Mefoxin, containing the cephalosporin cefoxitin sodium, is indicated for a variety of bacterial infections such as respiratory tract infections, urinary tract infections, skin and soft‑tissue infections, intra‑abdominal infections, and certain gynecologic infections when the causative organisms are susceptible.

Cefoxitin sodium inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins. This blocks the final cross‑linking step of peptidoglycan formation, causing cell‑wall weakness, osmotic instability and ultimately bacterial lysis.

The dosage of Mefoxin is determined by the prescribing clinician based on the type and severity of infection, patient age, weight, renal function and other clinical factors. Only a qualified healthcare professional should set the appropriate regimen.

Safety data for cefoxitin sodium in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Mefoxin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Mefoxin (cefoxitin) is a second‑generation cephalosporin offering broader activity against anaerobic organisms compared with many first‑generation agents. It provides reliable coverage for mixed aerobic‑anaerobic infections, whereas some later‑generation cephalosporins may have enhanced Gram‑negative activity but less anaerobic potency.

Mefoxin should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its stability.

Mefoxin is supplied for intramuscular injection. The healthcare professional selects the appropriate injection site and volume, and administers the dose according to aseptic technique and local clinical guidelines.

The most serious adverse reactions include severe allergic responses such as anaphylaxis, Clostridioides difficile‑associated colitis, and hematologic abnormalities like neutropenia. Prompt medical attention is required if any of these events occur.

Mefoxin is contraindicated in patients with a known hypersensitivity to cefoxitin, other cephalosporins, or any beta‑lactam antibiotics. Caution is also advised for individuals with severe renal impairment unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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