Product image of Megestrol Healthcare Med (Megestrol Acetate) supplied by GNH India

Megestrol Healthcare Med

Active Ingredient:
Megestrol Acetate
Origin:
EU

Megestrol Healthcare Med (Megestrol Acetate)

Megestrol acetate, the active ingredient in Megestrol Healthcare Med, is a synthetic progestin presented as an oral tablet for oral use. It is employed as an appetite stimulant in patients with cachexia and as hormone therapy for certain hormone‑sensitive cancers.

GNH India supplies Megestrol Healthcare Med as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Healthcare Med Kft.

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Indications & Clinical Uses

Megestrol acetate is used in clinical settings that involve hormone‑dependent conditions and severe weight loss.

  • Cachexia: improves appetite and promotes weight gain in patients with cancer‑related wasting.
  • Advanced breast cancer: provides antigonadotropic effects to help control tumor growth.
  • Endometrial cancer: acts as a hormonal therapy to inhibit disease progression.

How It Works

  • Megestrol acetate is a synthetic progestogen that binds to progesterone receptors, producing antigonadotropic effects that lower estrogen production. Its glucocorticoid activity also influences metabolic pathways, contributing to increased appetite and weight gain. The combined hormonal and glucocorticoid actions underlie its therapeutic effects in cancer hormone therapy and appetite stimulation.

Side Effects

Megestrol acetate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Edema: swelling of the lower extremities.
  • Weight gain: due to increased appetite and fluid retention.
  • Fatigue: general feeling of tiredness.
  • Mood changes: irritability or depression.
  • Hyperglycemia: elevated blood sugar levels.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Adrenal suppression: reduced endogenous cortisol production.
  • Hepatotoxicity: liver enzyme abnormalities.
  • Severe allergic reactions: rash, itching, swelling.
  • Cushingoid features: facial rounding, central obesity.
  • Menstrual irregularities: abnormal bleeding patterns.

Precautions & Warnings

When prescribing Megestrol acetate, clinicians should consider several safety measures.

  • Monitor blood glucose: patients with diabetes may require dose adjustments.
  • Assess thrombotic risk: avoid in individuals with a history of clotting disorders.
  • Evaluate liver function: periodic tests recommended for patients with hepatic disease.
  • Watch for adrenal insufficiency: taper off gradually after long‑term use.
  • Pregnancy and lactation: avoid use due to unknown safety profile.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Megestrol acetate can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): can reduce Megestrol levels.
  • Strong glucocorticoids: additive adrenal suppression.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: may require dose adjustment due to hyperglycemia.
  • Hormonal therapies (e.g., tamoxifen): potential antagonistic effects.
  • NSAIDs: increased risk of gastrointestinal irritation.

Frequently Asked Questions

Megestrol Healthcare Med, containing meg​estrol acetate, is prescribed to stimulate appetite in patients experiencing cancer‑related cachexia and as hormone therapy for advanced breast cancer and endometrial cancer. It works by influencing hormonal pathways that affect weight and tumor growth.

Megestrol acetate binds to progesterone receptors, producing antigonadotropic effects that lower estrogen levels. Its glucocorticoid‑like activity also stimulates appetite and alters metabolism, which together help manage weight loss and control hormone‑sensitive tumor growth.

The appropriate dose of Megestrol Healthcare Med is determined by the prescribing clinician based on the individual’s medical condition, response, and tolerability. Dosage regimens are not standardized and should follow the prescriber’s instructions.

The safety of meg​estrol acetate during pregnancy or lactation has not been established. It is generally avoided in pregnant or nursing individuals unless the potential benefits outweigh the possible risks, as determined by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Megestrol acetate differs from other appetite stimulants such as megestrol acetate’s progestogenic and glucocorticoid actions, offering both weight‑gain benefits and hormonal therapy for certain cancers. Alternatives like corticosteroids lack the same antigonadotropic effect, while other progestins may have different safety profiles.

Store Megestrol Healthcare Med at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Megestrol Healthcare Med is taken orally, typically as a tablet swallowed with water. The exact administration schedule, including timing relative to meals, should follow the prescribing clinician’s directions.

Serious risks include thromboembolic events such as deep‑vein thrombosis, adrenal suppression leading to cortisol deficiency, severe hyperglycemia, and rare cases of hepatotoxicity. Patients should be monitored regularly for these complications.

Megestrol Healthcare Med is contraindicated in individuals with known hypersensitivity to meg​estrol acetate, active thromboembolic disease, uncontrolled diabetes, or severe liver impairment. It should also be avoided in pregnant or nursing women unless clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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