Product image of Megestrol Oncoeurope (Megestrol Acetate) supplied by GNH India

Megestrol Oncoeurope

Active Ingredient:
Megestrol Acetate
Origin:
EU

Megestrol Oncoeurope (Megestrol Acetate)

Megestrol acetate, the active ingredient in Megestrol Oncoeurope, is a progestin presented as an oral tablet for oral use. It treats cachexia and anorexia associated with AIDS or cancer and is employed in hormone‑responsive cancers such as advanced breast cancer, endometrial carcinoma, and certain gynecologic tumors.

GNH India supplies Megestrol Oncoeurope as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Onco-Europe Ltd.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Megestrol acetate is indicated for conditions involving hormonal pathways and cancer‑related weight loss.

  • Cachexia and anorexia associated with AIDS or cancer: improves appetite and promotes weight gain.
  • Advanced breast cancer: provides antineoplastic effect in hormone‑responsive disease.
  • Endometrial carcinoma: used as hormonal therapy to control tumor growth.

How It Works

  • Megestrol acetate is a synthetic progestogen that binds to progesterone receptors, exerting antineoplastic effects in hormone‑responsive tumors and stimulating appetite through glucocorticoid‑like activity that modulates hypothalamic pathways and reduces pro‑inflammatory cytokine production.

Side Effects

Megestrol acetate may cause a range of adverse reactions.

Common Side Effects

  • Weight gain: increased adipose tissue accumulation.
  • Edema: fluid retention leading to swelling.
  • Nausea: mild gastrointestinal discomfort.
  • Fatigue: reduced energy levels.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Adrenal suppression: cortisol deficiency.
  • Hyperglycemia: elevated blood glucose levels.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess baseline weight and nutritional status: monitor changes regularly.
  • Screen for thromboembolic risk: evaluate history of clotting disorders.
  • Monitor blood glucose: especially in diabetic patients.
  • Check liver function: adjust if hepatic impairment is present.
  • Avoid use in pregnancy unless benefits outweigh risks: limited safety data.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Megestrol acetate can interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants: may increase bleeding risk.
  • CYP3A4 inducers (e.g., rifampin, phenytoin): reduce efficacy.
  • CYP3A4 inhibitors (e.g., ketoconazole): increase exposure.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycemics: may worsen hyperglycemia.
  • Other hormonal therapies: additive endocrine effects.
  • Corticosteroids: overlapping glucocorticoid activity.

Frequently Asked Questions

Megestrol Oncoeurope contains meg​estrol acetate, a progestin that is used as an appetite stimulant in patients with cancer‑related or AIDS‑related cachexia and as hormone therapy for certain hormone‑responsive cancers such as advanced breast cancer, endometrial carcinoma, and selected gynecologic tumors.

Megestrol acetate binds to progesterone receptors, producing antineoplastic effects in hormone‑sensitive tumors. It also exerts glucocorticoid‑like activity that influences hypothalamic pathways, reduces catabolic cytokines, and enhances appetite, leading to weight gain in patients with severe wasting.

The appropriate dose of Megestrol Oncoeurope is individualized by the prescribing clinician based on the patient’s condition, severity of cachexia, cancer type, and overall health status. No fixed regimen is provided here; the prescriber sets the dose and schedule.

Safety data for Megestrol acetate in pregnancy are limited, and the drug is generally avoided unless the potential benefit justifies the risk. It is also not recommended during breastfeeding because it may pass into milk and affect the infant. Consultation with a healthcare professional is essential.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Megestrol Oncoeurope. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Megestrol acetate is a progestin with both appetite‑stimulating and antineoplastic properties, distinguishing it from agents such as mirtazapine or dronabinol, which primarily act on central neurotransmitters. Its dual hormonal activity makes it especially useful in cancer‑related cachexia where tumor control is also a goal.

Megestrol Oncoeurope should be stored at ambient temperature below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Megestrol Oncoeurope is taken orally, typically as a tablet swallowed with water. The exact dosing schedule and whether it is taken with food are determined by the prescribing clinician based on the individual treatment plan.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, adrenal suppression leading to cortisol deficiency, severe hyperglycemia, and rare but life‑threatening allergic reactions. Patients should be monitored closely for signs of these conditions.

Megestrol Oncoeurope should be avoided in patients with known hypersensitivity to meg​estrol acetate, active uncontrolled thromboembolic disease, severe uncontrolled diabetes, or in those where pregnancy benefits outweigh potential risks. Clinicians must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.