Product image of Megestrol Pharmacenter (Megestrol Acetate) supplied by GNH India

Megestrol Pharmacenter

Active Ingredient:
Megestrol Acetate
Origin:
EU

Megestrol Pharmacenter (Megestrol Acetate)

Megestrol acetate, the active ingredient in Megestrol Pharmacenter, is a progestin presented as an oral tablet for oral use. It is employed as an appetite stimulant and as a hormonal therapy for certain cancers and for cachexia associated with AIDS or cancer, particularly in palliative care settings.

GNH India supplies Megestrol Pharmacenter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Pharmacenter Europe Kft.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Megestrol acetate is used in conditions where appetite stimulation or anti‑estrogenic hormonal therapy is required.

  • Cachexia associated with AIDS: improves appetite and promotes weight gain in patients with AIDS‑related wasting.
  • Cachexia associated with cancer: helps increase caloric intake and stabilise body weight in oncology patients.
  • Breast cancer: used as a hormonal agent to treat advanced or recurrent disease.
  • Endometrial cancer: employed as a progestogenic therapy for certain stages of the disease.
  • Appetite stimulation: prescribed to enhance food intake in patients with severe weight loss.

How It Works

  • Megestrol acetate is a synthetic progestogen that binds to intracellular progesterone receptors, modulating gene transcription. The receptor activation exerts anti‑estrogenic effects in hormone‑sensitive tissues and influences hypothalamic pathways that regulate hunger, thereby stimulating appetite. It also reduces circulating cortisol levels and may alter cytokine production, which together support weight gain.

Side Effects

Megestrol acetate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Weight gain: increase in body weight due to fluid retention or fat accumulation.
  • Edema: swelling of the limbs or face.
  • Nausea: mild to moderate feeling of sickness.
  • Vomiting: occasional episodes of stomach emptying.
  • Fatigue: general tiredness or lack of energy.
  • Hot flashes: transient warmth and sweating.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Hyperglycemia: elevated blood sugar levels, potentially precipitating diabetes.
  • Adrenal insufficiency: reduced cortisol production on abrupt discontinuation.
  • Liver dysfunction: abnormal liver enzymes or hepatitis.
  • Severe allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Megestrol acetate, clinicians should consider several safety precautions to minimise risk.

  • Assess baseline weight and nutritional status: evaluate before initiating therapy.
  • Monitor blood glucose: check fasting glucose periodically, especially in diabetic patients.
  • Evaluate for thrombotic risk: avoid in patients with history of clotting disorders.
  • Review liver function tests: perform baseline and periodic LFTs.
  • Consider adrenal function: taper gradually to prevent insufficiency.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Megestrol acetate can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk due to altered protein binding.
  • CYP3A4 inducers (e.g., rifampin, phenytoin): can reduce megesterol levels and effectiveness.
  • Glucocorticoids: concurrent use may exacerbate adrenal suppression.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: risk of hyperglycemia may require dose adjustment.
  • Hormonal therapies (e.g., tamoxifen): may interfere with anti‑estrogenic activity.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase megesterol exposure.

Frequently Asked Questions

Megestrol Pharmacenter contains megesterol acetate, a progestin that is prescribed to stimulate appetite in patients with severe weight loss and to provide hormonal therapy for certain hormone‑sensitive cancers such as breast and endometrial cancer, as well as for cachexia associated with AIDS or cancer.

Megesterol acetate binds to intracellular progesterone receptors, producing anti‑estrogenic effects in hormone‑sensitive tissues and modulating hypothalamic pathways that control hunger. This dual action helps increase food intake and also contributes to anti‑neoplastic activity in selected cancers.

The specific dose of Megestrol Pharmacenter is determined by the prescribing clinician based on the patient’s condition, weight, and response. Dosage regimens are individualized and should follow the prescriber’s instructions and local clinical guidelines.

Safety data for megesterol acetate in pregnancy and lactation are limited, and the product is generally not recommended for use in pregnant or nursing women unless the potential benefit outweighs the risk. Clinicians should evaluate each case carefully.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with corticosteroids such as dexamethasone, megesterol offers a longer‑acting appetite‑stimulating effect with a distinct hormonal mechanism. Unlike medroxyprogesterone acetate, megesterol has a broader indication set that includes both cachexia and hormone‑sensitive cancers, though individual response varies.

Megestrol Pharmacenter should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

The product is taken orally as a tablet, usually with a glass of water. It may be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels. Follow the prescriber’s guidance on timing and any dietary considerations.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, significant hyperglycemia that can precipitate diabetes, adrenal insufficiency on abrupt discontinuation, and severe liver dysfunction. Patients should be monitored for signs of these conditions throughout therapy.

Megestrol Pharmacenter is contraindicated in patients with known hypersensitivity to megesterol acetate, active thromboembolic disease, uncontrolled diabetes, or severe liver impairment. Caution is also advised for individuals with a history of adrenal insufficiency or those taking interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Megestrol Acetate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT