Product image of Megestrolacetaat Focus (Megestrol Acetate) supplied by GNH India

Megestrolacetaat Focus

Active Ingredient:
Megestrol Acetate
Origin:
EU

Megestrolacetaat Focus (Megestrol Acetate)

Megestrol acetate, the active ingredient in Megestrolacetaat Focus, is a progestin presented as an oral formulation for systemic use. It is employed to stimulate appetite in patients with cachexia related to AIDS or cancer and to treat hormone‑responsive breast and endometrial cancers.

GNH India supplies Megestrolacetaat Focus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, with robust quality assurance and regulatory compliance. The company ensures consistent batch release and traceability across all markets.

Manufacturer / TM Owner

Focus Care Pharmaceuticals B.V.

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Indications & Clinical Uses

Megestrol acetate is used in conditions where hormonal modulation or appetite stimulation is required, primarily in oncology and HIV‑related cachexia.

  • Cachexia associated with AIDS: improves appetite and promotes weight gain in patients with HIV‑related wasting.
  • Cachexia associated with cancer: helps restore nutritional status and body mass in oncology patients.
  • Breast cancer: used as part of hormonal therapy for hormone‑sensitive tumors.
  • Endometrial cancer: employed in the management of advanced or recurrent disease.

How It Works

  • Megestrol acetate is a synthetic progestogen that binds to progesterone receptors, influencing gene transcription and modulating glucocorticoid pathways. This receptor activation reduces catabolic signaling, enhances appetite centers in the hypothalamus, and exerts anti‑proliferative effects on hormone‑dependent tumor cells, thereby supporting weight gain and inhibiting tumor growth.

Side Effects

Megestrol acetate may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Weight gain: excess caloric retention and fluid accumulation.
  • Edema: peripheral swelling, especially in the lower extremities.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Fatigue: generalized tiredness or reduced energy.
  • Mood changes: irritability or mild depression.

Serious or Rare Side Effects

  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.
  • Adrenal suppression: signs of cortisol deficiency.
  • Hepatotoxicity: abnormal liver function tests or hepatitis.
  • Hyperglycemia: elevated blood glucose levels, particularly in diabetic patients.

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor for potential complications.

  • Assess baseline weight and nutritional status: document changes during treatment.
  • Evaluate thrombotic risk: consider prophylaxis in patients with history of clotting disorders.
  • Monitor blood glucose: especially in patients with diabetes or metabolic syndrome.
  • Check liver function tests periodically: detect early signs of hepatotoxicity.
  • Review concomitant hormone therapies: avoid additive hormonal effects.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Megestrol acetate can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce megesterol levels.
  • Glucocorticoids: additive effects on adrenal suppression.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: potential for hyperglycemia, requiring dose adjustment.
  • Antihypertensives: fluid retention may blunt blood pressure control.
  • Hormonal contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Megestrolacetaat Focus, containing meg​estrol acetate, is prescribed to stimulate appetite in patients with AIDS‑related or cancer‑related cachexia and as part of hormonal therapy for hormone‑sensitive breast and endometrial cancers.

Megestrol acetate binds to progesterone receptors, modulating gene expression and glucocorticoid pathways. This action reduces catabolic processes, enhances hypothalamic appetite signals, and exerts anti‑proliferative effects on certain hormone‑dependent tumor cells.

The specific dose and regimen are determined by the prescribing clinician based on the patient’s condition, weight, and response. Dosage may vary widely between cachexia management and oncologic indications.

Safety data are limited; meg​estrol acetate is generally avoided in pregnancy because of potential hormonal effects on the fetus. Breastfeeding is not recommended unless the benefits outweigh potential risks, and the prescriber should be consulted.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with corticosteroid‑based stimulants, meg​estrol acetate offers a progestogenic mechanism with longer‑lasting appetite improvement and additional anti‑neoplastic activity, making it suitable for patients who also need hormonal cancer control.

Store the product at ambient temperature below 25 °C, in the original container, protected from moisture, heat and direct sunlight to maintain stability and potency.

The medication is taken orally, usually as a tablet or capsule, with or without food as directed by the healthcare professional. Swallow the dosage form whole; do not crush or chew unless instructed.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, adrenal suppression leading to cortisol deficiency, significant hyperglycemia, and rare cases of severe liver injury. Patients should be monitored closely for these complications.

Patients with known hypersensitivity to meg​estrol acetate or any excipients, those with active thromboembolic disease, uncontrolled diabetes, severe liver impairment, or who are pregnant should avoid using this medication unless a prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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