Product image of Megexia (Megestrol Acetate) supplied by GNH India

Megexia

Active Ingredient:
Megestrol Acetate
Origin:
EU

Megexia (Megestrol Acetate)

Megestrol acetate, the active ingredient in Megexia, is a progestogen presented as a tablet for oral use. It stimulates appetite and possesses antineoplastic activity, making it useful in the management of cancer‑related cachexia, advanced breast cancer, endometrial cancer, and hormone therapy for endometrial hyperplasia.

GNH India supplies Megexia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, adhering to EU GMP standards and offering reliable global distribution. The product is manufactured under strict quality controls to meet international regulatory requirements.

Manufacturer / TM Owner

Sophos Biotech Srl

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Indications & Clinical Uses

Megexia (megestrol acetate) acts on hormonal pathways and is indicated for the following conditions:

  • Cachexia (AIDS or cancer): improves appetite and promotes weight gain in affected patients.
  • Advanced breast cancer: provides antineoplastic effect and may reduce tumor progression.
  • Endometrial cancer: used as hormonal therapy to inhibit tumor growth.
  • Endometrial hyperplasia: administered to control abnormal endometrial proliferation.

How It Works

  • Megestrol acetate is a synthetic progestogen that binds to progesterone receptors and also exhibits glucocorticoid activity. Receptor activation modulates gene expression that enhances appetite, reduces catabolism, and exerts anti‑estrogenic effects in hormone‑sensitive tumors, contributing to its antineoplastic and hormone‑therapy actions.

Side Effects

Megexia may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Nausea
  • Vomiting
  • Weight gain
  • Edema
  • Fatigue
  • Menstrual irregularities

Serious or Rare Side Effects

  • Thromboembolic events
  • Adrenal suppression
  • Severe allergic reaction (anaphylaxis)
  • Hyperglycemia or new‑onset diabetes
  • Cushingoid syndrome

Precautions & Warnings

Before initiating Megexia, clinicians should consider several safety measures.

  • Assess nutritional status: monitor weight and appetite regularly.
  • Screen for thromboembolic risk: evaluate history of clotting disorders.
  • Monitor blood glucose: watch for hyperglycemia, especially in diabetic patients.
  • Evaluate adrenal function: consider cortisol levels during prolonged therapy.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Megexia can interact with other medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations of megestrol acetate.
  • Anticoagulants (e.g., warfarin): may enhance bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effectiveness.
  • Diabetes medications: hyperglycemic effect of megestrol may require dose adjustment.
  • Hormonal contraceptives: may decrease contraceptive efficacy.

Frequently Asked Questions

Megexia contains megestrol acetate and is used as an appetite stimulant in patients with cancer‑related or AIDS‑related cachexia, as well as a hormonal therapy for advanced breast cancer, endometrial cancer, and for managing endometrial hyperplasia.

Megestrol acetate binds to progesterone receptors and also displays glucocorticoid activity. This dual action modulates gene transcription that increases appetite, reduces catabolic processes, and exerts anti‑estrogenic effects that help control hormone‑sensitive tumors.

The dose of Megexia is individualized by the prescribing clinician based on the specific indication, patient weight, clinical response, and tolerance. No fixed regimen is provided here; the prescriber sets the appropriate dosage.

Safety data for megestrol acetate in pregnancy and lactation are limited, and the product is generally not recommended for use in pregnant or nursing women unless the potential benefit justifies the potential risk. Consultation with a healthcare professional is essential.

To request Megexia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other appetite stimulants such as dronabinol or mirtazapine, Megexia (megestrol acetate) offers both appetite‑enhancing and antineoplastic properties, making it particularly useful in cancer‑related cachexia. Its progestogenic profile may lead to different side‑effect patterns, such as hormonal changes, which should be considered when selecting therapy.

Megexia tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid environments such as bathrooms.

Megexia is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration schedule, including timing and whether it should be taken with meals, is determined by the treating clinician.

Serious risks include thromboembolic events, adrenal suppression, severe allergic reactions, hyperglycemia that may precipitate diabetes, and Cushing‑like syndrome. Patients should be monitored closely for signs of these conditions, especially during long‑term therapy.

Megexia should be avoided in patients with known hypersensitivity to megestrol acetate, active thromboembolic disease, uncontrolled diabetes, severe infection, or those receiving concurrent strong CYP3A4 inhibitors without appropriate monitoring. Pregnant or nursing women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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