Product image of Mekrazym (Amylase, Lipase, Protease) supplied by GNH India

Mekrazym

Active Ingredient:
Amylase, Lipase, Protease
Origin:
EU

Mekrazym (Amylase, Lipase, Protease)

Amylase, Lipase, and Protease, the active ingredients in Mekrazym, are a digestive enzyme supplement presented as an oral formulation for oral use. It supports the breakdown of carbohydrates, fats and proteins in individuals with enzyme deficiency or malabsorption.

GNH India supplies Mekrazym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alfasigma S.P.A.

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Indications & Clinical Uses

Mekrazym provides exogenous digestive enzymes to aid nutrient breakdown in conditions where endogenous production is insufficient.

  • Exocrine pancreatic insufficiency: improves digestion and nutrient absorption.
  • Cystic fibrosis‑related malabsorption: enhances fat and protein utilization.
  • Chronic pancreatitis: reduces steatorrhea and abdominal discomfort.
  • Post‑surgical pancreatic resection: supports recovery of digestive function.

How It Works

  • Mekrazym delivers amylase, lipase and protease directly to the gastrointestinal tract. Amylase catalyzes the hydrolysis of starches into sugars, lipase hydrolyzes triglycerides into fatty acids and monoglycerides, and protease cleaves peptide bonds to release amino acids. By supplementing these enzymes, the product compensates for deficient endogenous secretion, facilitating more complete macronutrient digestion and absorption.

Side Effects

Adverse reactions may occur with any oral enzyme supplement.

Common Side Effects

  • Mild abdominal discomfort or bloating.
  • Flatulence or increased gas production.
  • Nausea or transient loss of appetite.
  • Soft stools or mild diarrhea.
  • Unpleasant taste or after‑taste.

Serious or Rare Side Effects

  • Allergic reaction such as rash, itching, swelling, or anaphylaxis.
  • Severe abdominal pain with vomiting.
  • Persistent or worsening diarrhea leading to dehydration.
  • Pancreatitis flare in susceptible individuals.
  • Unexplained weight loss despite adequate intake.

Precautions & Warnings

Mekrazym should be used with awareness of specific safety considerations.

  • Assess pancreatic function: confirm enzyme deficiency before initiating therapy.
  • Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Adjust dose in renal or hepatic impairment only under medical guidance.
  • Avoid concomitant use with antacids that may inactivate enzymes unless advised.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Enzyme supplements can interact with certain medications and foods.

Major Interactions (Avoid)

  • Proton pump inhibitors or high‑dose antacids: may reduce enzyme activity.
  • Certain antibiotics (e.g., tetracycline): can bind to enzymes and diminish effectiveness.

Moderate Interactions (Monitor Closely)

  • Warfarin: monitor INR as altered vitamin K absorption may affect anticoagulation.
  • Oral contraceptives: observe for changes in hormone levels due to altered gut absorption.
  • Fat‑soluble vitamins (A, D, E, K): consider supplementation if deficiency is suspected.

Frequently Asked Questions

Mekrazym is an oral digestive enzyme supplement containing amylase, lipase and protease. It is used to aid the digestion of carbohydrates, fats and proteins in patients with enzyme‑deficient conditions such as exocrine pancreatic insufficiency, cystic fibrosis‑related malabsorption, chronic pancreatitis, or after pancreatic surgery.

Amylase breaks down complex carbohydrates into simple sugars, lipase hydrolyzes dietary fats into fatty acids and monoglycerides, and protease cleaves protein molecules into amino acids and small peptides. By providing these enzymes directly to the gut, Mekrazym compensates for reduced endogenous secretion and promotes more complete nutrient absorption.

The appropriate dose of Mekrazym is individualized and must be determined by a qualified healthcare professional based on the patient’s specific condition, severity of enzyme deficiency, and dietary intake. Patients should follow the prescriber’s instructions and not alter the dosing regimen without medical advice.

Safety data for Mekrazym in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their obstetrician or healthcare provider.

To request Mekrazym, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mekrazym combines three key enzymes—amylase, lipase and protease—in a single oral formulation, offering broad macronutrient coverage. Compared with products that contain only lipase or a limited enzyme mix, Mekrazym may provide more comprehensive digestion support, especially when patients have mixed carbohydrate, fat and protein malabsorption.

Store Mekrazym at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat and direct sunlight. Do not refrigerate or freeze unless the label specifically advises otherwise.

Mekrazym is taken orally, usually with meals or snacks that contain the nutrients to be digested. The tablets or capsules should be swallowed whole with a glass of water unless the prescribing information indicates otherwise.

The most serious risks include allergic reactions that may manifest as rash, swelling, difficulty breathing or anaphylaxis, and rare cases of severe abdominal pain or pancreatitis exacerbation. Patients should seek immediate medical attention if they experience any signs of a serious hypersensitivity reaction or persistent severe gastrointestinal symptoms.

Mekrazym should be avoided by individuals with known hypersensitivity to any of its enzyme components, those who have experienced severe allergic reactions to similar enzyme products, and patients with active pancreatitis unless directed by a physician. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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