Product image of Mekrazym (Amylase, Lipase, Protease) supplied by GNH India

Mekrazym

Active Ingredient:
Amylase, Lipase, Protease
Origin:
EU

Mekrazym (Amylase, Lipase, Protease)

Amylase, Lipase, Protease, the active ingredients in Mekrazym, are digestive enzymes presented as an oral formulation for oral use. They assist the hydrolysis of carbohydrates, fats, and proteins to support normal digestion in adults and children with enzyme insufficiency, such as exocrine pancreatic insufficiency.

GNH India supplies Mekrazym as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide under stringent quality assurance protocols.

Manufacturer / TM Owner

Alfasigma España, S.L.

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Indications & Clinical Uses

Mekrazym, an oral enzyme preparation, is used to aid digestion in conditions characterized by insufficient pancreatic enzyme activity.

  • Exocrine pancreatic insufficiency: improves digestion and nutrient absorption in patients with reduced pancreatic enzyme output.
  • Cystic fibrosis–related malabsorption: enhances breakdown of dietary fats, proteins, and carbohydrates to support growth and nutritional status.
  • Post‑pancreatic surgery: provides supplemental enzymes to maintain adequate digestion after resection of pancreatic tissue.

How It Works

  • Mekrazym contains amylase, lipase, and protease enzymes that catalyze the hydrolysis of dietary carbohydrates, triglycerides, and proteins, respectively. By breaking these macronutrients into absorbable sugars, fatty acids, and amino acids, the preparation compensates for deficient endogenous pancreatic secretion, facilitating normal gastrointestinal absorption and reducing maldigestion.

Side Effects

Mekrazym may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Abdominal discomfort or cramping
  • Flatulence or bloating
  • Diarrhea or loose stools
  • Nausea or mild vomiting
  • Unpleasant taste or after‑taste
  • Mild skin rash or itching

Serious or Rare Side Effects

  • Anaphylactic reaction or severe allergic response
  • Angioedema involving face, lips, or tongue
  • Severe abdominal pain with signs of pancreatitis

Precautions & Warnings

When considering Mekrazym, several precautionary measures should be observed to ensure safe use.

  • Assess pancreatic function before initiating therapy: confirm enzyme deficiency.
  • Monitor for allergic reactions: discontinue if rash or swelling develops.
  • Use with caution in patients with known hypersensitivity to enzyme preparations.
  • Avoid concomitant use of high‑dose antacids that may inactivate enzymes.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Mekrazym can interact with certain medications, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Proton pump inhibitors: may reduce enzyme activity by increasing gastric pH.
  • Antacids containing aluminum or magnesium: can bind enzymes and diminish their effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduced absorption of hormone components.
  • Broad‑spectrum antibiotics: alteration of gut flora may affect enzyme activity.
  • High‑fat meals: may require dose adjustment to maintain optimal digestion.

Frequently Asked Questions

Mekrazym is an oral enzyme preparation used to support digestion in individuals with insufficient pancreatic enzyme production. It helps break down carbohydrates, fats, and proteins, making nutrients more absorbable in conditions such as exocrine pancreatic insufficiency, cystic fibrosis‑related malabsorption, and after pancreatic surgery.

The three enzymes act on specific macronutrients: amylase hydrolyzes starches into simple sugars, lipase splits triglycerides into fatty acids and glycerol, and protease cleaves proteins into amino acids and peptides. Together they compensate for deficient pancreatic secretions, facilitating normal gastrointestinal digestion and nutrient uptake.

The appropriate dose of Mekrazym is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of enzyme deficiency, and dietary needs. No fixed regimen is provided here; the prescriber will tailor the amount to achieve optimal digestive support.

Limited clinical data are available on the use of Mekrazym in pregnancy or lactation. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential benefits and risks with their healthcare provider before starting therapy.

To order Mekrazym, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mekrazym contains a combination of amylase, lipase, and protease similar to other pancreatic enzyme replacements such as Creon or Pancreaze. The primary differences lie in formulation, enzyme activity units, and excipients. Clinical effectiveness is comparable when dosed appropriately, but individual patient response and tolerability may vary, so selection should be guided by the prescriber.

Mekrazym should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the container tightly closed and out of direct sunlight. Do not use the product after the expiration date printed on the label.

Mekrazym is taken orally, usually with meals or snacks that contain food. The tablets or capsules should be swallowed whole with a sufficient amount of water, unless the prescribing information advises otherwise. Consistent timing with meals helps maximize the digestive benefit.

The most serious risks include severe allergic reactions such as anaphylaxis or angioedema, which require immediate medical attention. In rare cases, patients may experience severe abdominal pain indicating pancreatitis exacerbation. Any signs of difficulty breathing, swelling of the face or throat, or intense abdominal discomfort should prompt urgent evaluation.

Mekrazym should be avoided by individuals with a known hypersensitivity to any of its enzyme components or excipients. Patients with a history of severe allergic reactions to pancreatic enzyme preparations should not use this product without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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