Product image of Mel Max Actigel (Diclofenac Sodium) supplied by GNH India

Mel Max Actigel

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Mel Max Actigel (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Mel Max Actigel, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical gel for cutaneous use. It is employed to relieve mild to moderate pain and to reduce inflammation in musculoskeletal conditions, acting locally on the skin over the affected area.

GNH India supplies Mel Max Actigel as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Diclofenac sodium in Mel Max Actigel is applied topically to manage pain and inflammation within the musculoskeletal system.

  • Musculoskeletal pain: provides localized analgesia and diminishes inflammatory swelling.
  • Osteoarthritis of peripheral joints: reduces joint discomfort and improves function.
  • Soft‑tissue injuries (sprains, strains, bruises): alleviates pain and limits local inflammation.
  • Tendinitis and bursitis: helps control inflammation and associated tenderness.

How It Works

  • Diclofenac sodium reversibly inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in peripheral tissues, decreasing the synthesis of prostaglandins that mediate inflammation, pain, and fever. By limiting prostaglandin production at the site of application, the gel reduces vascular permeability, edema, and nociceptor sensitisation, resulting in analgesic and anti‑inflammatory effects localized to the treated area.

Side Effects

Topical diclofenac may cause skin‑related reactions and, rarely, systemic adverse events.

Common Side Effects

  • Skin irritation: mild burning or stinging at the application site.
  • Redness: localized erythema where the gel is applied.
  • Itching: pruritus confined to the treated area.
  • Dryness: transient dryness or flaking of the skin.
  • Rash: mild maculopapular eruption.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, angio‑edema, or anaphylaxis.
  • Severe skin disorders: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic NSAID effects: gastrointestinal ulceration, renal impairment, or hepatic dysfunction.
  • Blood dyscrasias: rare cases of agranulocytosis or thrombocytopenia.
  • Cardiovascular events: increased risk of thrombotic events in susceptible individuals.

Precautions & Warnings

When using Mel Max Actigel, consider the following safety measures.

  • Apply to intact skin: avoid broken, infected, or inflamed areas.
  • Limit area of application: do not exceed the recommended surface area (usually not more than 10 % of body surface).
  • Avoid occlusion: do not cover the treated area with airtight dressings unless directed by a healthcare professional.
  • Monitor for systemic effects: be alert to signs of gastrointestinal bleeding, renal dysfunction, or hepatic issues, especially with prolonged use.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac sodium gel can interact with systemic medications and other topical agents.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal and renal toxicity.
  • Lithium: heightened lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: potential for reduced renal function.
  • Selective serotonin reuptake inhibitors (SSRIs): modestly increased bleeding risk.
  • Alcohol: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Mel Max Actigel is a topical formulation of diclofenac sodium indicated for the relief of mild to moderate pain and the reduction of inflammation associated with musculoskeletal conditions such as osteoarthritis, sprains, strains, tendinitis, and bursitis. It is applied directly to the skin over the affected area to provide localized analgesic and anti‑inflammatory effects.

Diclofenac sodium works by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, the drug diminishes inflammation, pain signalling, and fever responses at the site where it is applied.

The specific amount to apply is determined by the prescribing healthcare professional based on the severity of symptoms and the size of the treatment area. Typically, a thin layer is spread over the affected skin and gently massaged in, with frequency and duration guided by the prescriber’s instructions.

Safety data for topical diclofenac during pregnancy and lactation are limited. Because systemic absorption can occur, it is generally advised to avoid use unless the potential benefit outweighs the risk and the prescriber explicitly recommends it. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Mel Max Actigel contains diclofenac sodium, which is among the most potent topical NSAIDs for musculoskeletal pain. Compared with ibuprofen or ketoprofen gels, diclofenac often achieves higher skin penetration and longer duration of action, leading to more pronounced analgesia. However, individual response varies, and choice of product should consider efficacy, tolerability, and any patient‑specific contraindications.

Store the gel at room temperature, ideally below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the lid tightly closed when not in use. Do not freeze the product, and avoid exposing it to extreme heat, which could affect its consistency and potency.

The gel is applied topically to clean, dry skin over the painful or inflamed area. Use a thin, even layer and gently massage until fully absorbed. Wash hands after application unless the hands are the treatment site. Follow the prescriber’s frequency recommendations, typically 2‑4 times daily, and avoid covering the area with occlusive dressings unless directed.

Serious adverse reactions, though rare, include severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, systemic allergic responses like anaphylaxis, and systemic NSAID effects such as gastrointestinal bleeding, renal impairment, or hepatic dysfunction. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, blistering, severe stomach pain, blood in stool, or signs of kidney or liver injury.

Mel Max Actigel should be avoided in individuals with known hypersensitivity to diclofenac, other NSAIDs, or any excipients in the gel. It is also contraindicated on broken, infected, or inflamed skin, and in patients with a history of severe cardiovascular, renal, or hepatic disease where systemic NSAID exposure is a concern. Consultation with a healthcare professional is essential before use in these populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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