Product image of Mel (Meloxicam) supplied by GNH India

Mel

Active Ingredient:
Meloxicam
Origin:
EU

Mel (Meloxicam)

Meloxicam, the active ingredient in Mel, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for systemic use. It reduces inflammation and pain associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute musculoskeletal pain in adult patients.

GNH India supplies Mel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and provides regulatory documentation for each batch. Its global distribution network ensures timely delivery to diverse healthcare settings, supporting patient care across multiple regions.

Manufacturer / TM Owner

Hasco-Lek

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Indications & Clinical Uses

Meloxicam is indicated for several inflammatory and degenerative joint conditions where COX‑2 mediated prostaglandin production contributes to pain and swelling.

  • Osteoarthritis: reduces joint pain and improves functional mobility in patients with degenerative cartilage loss.
  • Rheumatoid arthritis: alleviates inflammatory joint pain and stiffness in autoimmune synovitis.
  • Ankylosing spondylitis: diminishes spinal inflammation and associated chronic back pain.
  • Acute pain: provides short‑term relief of moderate to severe musculoskeletal pain.

How It Works

  • Meloxicam selectively inhibits the cyclooxygenase‑2 (COX‑2) enzyme, decreasing the conversion of arachidonic acid to prostaglandins that mediate inflammation, pain and fever. By sparing COX‑1 activity, it aims to preserve gastric mucosal protection while delivering anti‑inflammatory and analgesic effects. The reduced prostaglandin synthesis leads to lowered vascular permeability and leukocyte infiltration at sites of tissue injury.

Side Effects

Meloxicam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dyspepsia or nausea.
  • Headache.
  • Dizziness.
  • Mild skin rash.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding.
  • Cardiovascular events such as heart attack or stroke.
  • Liver enzyme elevation or hepatitis.
  • Severe renal impairment or anaphylaxis.

Precautions & Warnings

When prescribing meloxicam, clinicians should evaluate patient risk factors and monitor for potential complications.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor blood pressure: NSAIDs can raise systolic and diastolic values.
  • Evaluate renal function: use caution in patients with impaired kidney function.
  • Review hepatic status: periodic liver enzyme testing is advisable.
  • Avoid concomitant use with other NSAIDs or COX‑2 inhibitors unless medically justified.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Meloxicam can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Lithium: increased serum lithium levels.
  • Methotrexate: amplified toxicity risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible renal function changes.
  • Diuretics: may affect blood pressure control.
  • SSRIs or SNRIs: modest increase in bleeding tendency.

Frequently Asked Questions

Mel is prescribed to manage pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other acute musculoskeletal pain conditions. It helps improve joint function and reduces discomfort in adult patients.

Meloxicam works by selectively inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which lowers the production of prostaglandins—chemical mediators that drive inflammation, pain, and fever. This targeted action provides anti‑inflammatory and analgesic benefits while sparing COX‑1 activity.

The appropriate dose of meloxicam is determined by the prescribing healthcare professional based on the patient’s condition, severity, and overall health. Dosage may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety of meloxicam in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Mel, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Meloxicam offers relatively selective COX‑2 inhibition, which may reduce the risk of gastrointestinal irritation compared with non‑selective NSAIDs. However, it shares similar cardiovascular and renal safety considerations, and the choice of NSAID should be individualized based on patient risk factors and therapeutic goals.

Meloxicam should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Meloxicam is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber to ensure optimal absorption and tolerability.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, severe liver injury, acute renal failure, and life‑threatening hypersensitivity reactions like anaphylaxis. Patients should seek immediate medical attention if they experience any of these symptoms.

Meloxicam is contraindicated in individuals with known hypersensitivity to meloxicam or other NSAIDs, those with active gastrointestinal bleeding or ulceration, and patients with severe renal or hepatic impairment. It should also be avoided in patients taking certain anticoagulants or other drugs that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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