Product image of Meladinine (Methoxsalen) supplied by GNH India

Meladinine

Active Ingredient:
Methoxsalen
Origin:
EU

Meladinine (Methoxsalen)

Methoxsalen, the active ingredient in Meladinine, is a psoralen presented as a topical formulation for skin use. It is employed in the management of certain pigmentary and proliferative skin disorders, primarily in adult patients.
GNH India supplies Meladinine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mitem Pharma

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Indications & Clinical Uses

Methoxsalen acts as a photosensitizing agent used in dermatology to modify disease activity in light‑dependent therapies.

  • Vitiligo: promotes repigmentation of depigmented patches when combined with UVA exposure.
  • Psoriasis: reduces scaling and erythema of plaques as part of PUVA treatment.
  • PUVA adjunct therapy: enhances therapeutic response in selected skin conditions requiring UVA phototherapy.

How It Works

  • Methoxsalen intercalates into DNA strands and, upon activation by UVA radiation, forms covalent cross‑links between DNA bases. These cross‑links inhibit DNA synthesis and cell proliferation, leading to antiproliferative and immunosuppressive effects in the epidermis, which underlie its therapeutic action in pigmentary and hyperproliferative skin disorders.

Side Effects

Methoxsalen may cause a range of skin‑related and systemic reactions.

Common Side Effects

  • Erythema: redness of the treated skin area.
  • Pruritus: itching at the application site.
  • Burning sensation: transient discomfort during UVA exposure.
  • Hyperpigmentation: darkening of treated skin.
  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Blistering: formation of vesicles or bullae on exposed skin.
  • Severe photosensitivity: exaggerated skin reaction to light.
  • Cutaneous squamous cell carcinoma: potential long‑term risk with extensive use.
  • Systemic toxicity: rare hepatic or renal effects.
  • Anaphylaxis: extremely rare hypersensitivity reaction.

Precautions & Warnings

When using Methoxsalen, several safety measures should be observed.

  • Sun exposure: avoid direct sunlight on treated areas for at least 24 hours after application.
  • Protective eyewear: wear UVA‑blocking glasses during phototherapy sessions.
  • Concomitant photosensitizers: do not use other photosensitizing drugs simultaneously.
  • Skin monitoring: inspect treated skin regularly for abnormal reactions.
  • Pregnancy: safety not established; avoid use unless clearly indicated.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Methoxsalen can interact with other medications that affect photosensitivity or skin healing.

Major Interactions (Avoid)

  • Tetracyclines: increase risk of severe photosensitivity.
  • Thiazide diuretics: potentiate phototoxic reactions.
  • Retinoids: heighten skin irritation and erythema.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may modestly increase photosensitivity.
  • Antifungal agents (e.g., ketoconazole): possible additive skin effects.
  • Oral contraceptives: monitor for enhanced photosensitivity.

Frequently Asked Questions

Meladinine contains methoxsalen, a psoralen that is used as a photosensitizing agent in dermatology. It is prescribed primarily for vitiligo to promote repigmentation and for psoriasis to reduce plaque scaling and redness when combined with UVA phototherapy.

Methoxsalen intercalates into DNA and, after activation by UVA light, creates DNA cross‑links that inhibit cell proliferation. This antiproliferative and immunosuppressive effect helps normalize skin cell turnover and modulates pigment production, supporting therapeutic outcomes in vitiligo and psoriasis.

The specific dose and application schedule of Meladinine are determined by the prescribing clinician based on the patient’s condition, skin type, and the planned UVA exposure. Dosage instructions are individualized and should follow the healthcare professional’s guidance.

The safety of methoxsalen in pregnancy and lactation has not been established. It is generally advised to avoid use unless the potential benefit justifies the potential risk, and this decision should be made by a qualified healthcare provider.

To request Meladinine, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Meladinine’s active ingredient, methoxsalen, is the most commonly used psoralen for PUVA therapy. Compared with alternative psoralens, it has a well‑characterized safety profile and extensive clinical experience, making it a standard choice for dermatologists managing vitiligo and psoriasis.

Meladinine should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from direct light, moisture, and extreme temperatures to maintain stability and potency.

Meladinine is a topical preparation applied to the affected skin areas as directed by the prescriber. After the appropriate waiting period, the treated skin is exposed to a controlled dose of UVA light (PUVA) under medical supervision.

Serious risks include severe photosensitivity reactions such as blistering, potential long‑term increased risk of cutaneous squamous cell carcinoma, and rare systemic toxicity. Patients should be monitored closely for any adverse skin changes during treatment.

Meladinine is contraindicated in individuals with known hypersensitivity to methoxsalen or other psoralens, those with active skin infections, and patients taking other strong photosensitizing agents. It should also be used with caution in pregnant or nursing women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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