Product image of Melatal (Melatonin) supplied by GNH India

Melatal

Active Ingredient:
Melatonin
Origin:
EU

Melatal (Melatonin)

Melatonin, the active ingredient in Melatal, is a melatonin receptor agonist presented as an oral formulation for oral use. It helps regulate the sleep‑wake cycle and is used to treat sleep disorders such as insomnia in adults. By binding to MT1 and MT2 receptors in the suprachiasmatic nucleus, it supports the natural circadian rhythm, facilitating the onset and maintenance of sleep.

GNH India supplies Melatal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured under EU regulations and meets the quality standards required for global distribution.

Manufacturer / TM Owner

Vitabalans Oy

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Indications & Clinical Uses

Melatal is indicated for several sleep‑related conditions that involve disruption of the circadian rhythm.

  • Primary insomnia: assists adults in initiating and maintaining sleep, improving total sleep time.
  • Delayed sleep phase disorder: advances sleep onset timing, helping align the internal clock with desired bedtime.
  • Jet lag: reduces the time needed to adjust to new time zones, promoting quicker adaptation of the sleep‑wake cycle.

How It Works

  • Melatonin acts as an agonist at the MT1 and MT2 melatonin receptors located in the suprachiasmatic nucleus of the hypothalamus. Activation of these receptors modulates the circadian rhythm, signaling the body that it is time to prepare for sleep, thereby facilitating the onset and maintenance of a regular sleep pattern.

Side Effects

Melatonin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during daytime.
  • Headache: mild to moderate pain in the head region.
  • Dizziness: sensation of light‑headedness or imbalance.
  • Nausea: feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Mood changes: emergence of depression, agitation, or anxiety.
  • Hormonal effects: alterations in reproductive hormone levels, potentially affecting menstrual cycles.

Precautions & Warnings

When prescribing Melatal, clinicians should consider several safety aspects to minimize risk.

  • Age limitation: use is generally recommended for adults; pediatric use should be evaluated by a physician.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Anticoagulant therapy: assess bleeding risk when combined.
  • Pregnancy and lactation: avoid unless benefits outweigh potential risks.
  • Underlying medical conditions: evaluate hepatic or renal impairment before use.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Melatonin can interact with other medicines, altering their effects or increasing adverse reactions.

Major Interactions (Avoid)

  • Warfarin: may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): potential reduction in immunosuppressive efficacy.
  • Oral contraceptives: possible hormonal interaction affecting contraceptive reliability.

Moderate Interactions (Monitor Closely)

  • Sedative antihistamines: enhanced drowsiness.
  • Antidiabetic agents: risk of hypoglycemia, requiring glucose monitoring.

Frequently Asked Questions

Melatal contains melatonin and is used to treat sleep‑related conditions such as primary insomnia, delayed sleep phase disorder, and jet lag. By supporting the body’s natural circadian rhythm, it helps individuals fall asleep more easily and maintain a regular sleep pattern.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This activation signals the body that it is nighttime, helping to synchronize the internal clock and promote the physiological processes that lead to sleep onset and maintenance.

The appropriate dose of Melatal is determined by a qualified prescriber based on the patient’s age, condition, and response to therapy. Dosage recommendations are not standardized in public literature and should follow the prescribing information provided by the healthcare professional.

Safety data for melatonin use in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a healthcare provider after a thorough risk‑benefit assessment.

To order Melatal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Unlike benzodiazepines or non‑benzodiazepine hypnotics, melatonin works by normalising the circadian rhythm rather than depressing the central nervous system. This mechanism generally results in fewer next‑day residual effects, but efficacy may be limited to disorders directly linked to rhythm disruption, whereas other agents may be more suitable for severe insomnia.

Melatal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure the packaging remains tightly closed until use to maintain stability.

Melatal is taken orally, usually as a tablet or capsule, with water. It is commonly taken shortly before bedtime, but the exact timing and any specific administration instructions should be followed as directed by the prescribing clinician.

Serious risks, although rare, include allergic reactions such as rash, swelling, or difficulty breathing, and significant mood changes like depression or agitation. Patients should seek immediate medical attention if they experience any of these symptoms while using melatonin.

Melatal should be avoided by individuals with known hypersensitivity to melatonin, those taking certain anticoagulants or immunosuppressants without medical supervision, and pregnant or breastfeeding women unless a healthcare professional determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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