Product image of Melatonin Ab (Melatonin) supplied by GNH India

Melatonin Ab

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Ab (Melatonin)

Melatonin, the active ingredient in Melatonin Ab, is a melatonin receptor agonist presented as an oral dosage form for oral use. It helps regulate circadian rhythm and promotes sleep onset, addressing insomnia and related sleep‑wake rhythm disorders, including jet lag, in adult patients.

GNH India supplies Melatonin Ab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and adherence to European Union manufacturing standards. Our distribution network provides reliable access across multiple regions.

Manufacturer / TM Owner

Aurobindo N.V.

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Indications & Clinical Uses

Melatonin is used to address sleep‑related conditions by acting on the melatonin receptor pathway.

  • Insomnia: Improves sleep onset and reduces nighttime awakenings.
  • Sleep‑wake rhythm disorders: Helps synchronize disrupted circadian rhythms.
  • Jet lag: Facilitates adjustment to new time zones and reduces fatigue after long‑distance travel.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. This interaction modulates the circadian clock, decreases neuronal firing during the night, and promotes the physiological processes that initiate and maintain sleep, thereby facilitating sleep onset and improving sleep continuity.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Mild vivid dreams

Serious or Rare Side Effects

  • Allergic reaction (rash, itching, swelling)
  • Severe skin eruption
  • Mood changes or depression
  • Marked daytime sleepiness affecting activities
  • Rare cases of hypotension

Precautions & Warnings

When using Melatonin Ab, consider the following precautions.

  • Assess renal function: adjust use in severe impairment.
  • Avoid operating machinery if drowsy.
  • Consult physician if taking anticoagulants or other CNS depressants.
  • Use with caution in elderly patients due to increased sensitivity.
  • Pregnancy and lactation: safety not established; discuss with healthcare provider.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may alter melatonin metabolism.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): additive sedation.
  • Antidepressants (e.g., SSRIs): may affect sleep architecture.
  • Oral contraceptives: may increase melatonin plasma levels.

Frequently Asked Questions

Melatonin Ab is an oral melatonin supplement indicated for the short‑term management of insomnia, sleep‑wake rhythm disorders and jet lag in adult patients. It works by supporting the body’s natural circadian rhythm to promote sleep onset and improve sleep quality.

Melatonin mimics the body’s natural hormone by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. This interaction signals nighttime, helping to synchronize the internal clock, reduce neuronal activity, and facilitate the physiological processes that initiate and maintain sleep.

The appropriate dose of Melatonin Ab is determined by the prescribing healthcare professional based on the individual’s condition, age, and response. Typical adult regimens range from low to moderate doses, but exact dosing should always follow the prescriber’s instructions.

Safety data for melatonin use in pregnancy and lactation are limited. Because the risk cannot be ruled out, it should only be used if the potential benefit justifies the potential risk, and only after consultation with a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature requirements) and the necessary import documentation.

Unlike benzodiazepines or antihistamines, melatonin works by restoring the natural circadian signal rather than depressing central nervous system activity. This generally results in fewer next‑day residual effects, but efficacy may be limited to specific sleep‑related disorders such as jet lag or shift‑work sleep disturbance.

Store Melatonin Ab at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Melatonin Ab is taken orally, usually with a glass of water. It can be taken with or without food, although some patients prefer taking it 30‑60 minutes before bedtime to align with the natural rise in endogenous melatonin levels.

Serious risks, although rare, include allergic reactions such as rash, itching or swelling, and significant mood changes like depression or severe daytime drowsiness that may impair daily activities. Any signs of an allergic response or unexpected behavioral changes should prompt immediate medical evaluation.

Individuals with known hypersensitivity to melatonin or any excipients in the formulation should avoid the product. It is also not recommended for patients with severe hepatic impairment, children, or anyone for whom a prescriber determines that the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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