Product image of Melatonin Al (Melatonin) supplied by GNH India

Melatonin Al

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Al (Melatonin)

Melatonin, the active ingredient in Melatonin Al, is a melatonin receptor agonist presented as a unknown/unknown for oral use. It treats insomnia, jet lag and sleep‑wake rhythm disorders in adults.
GNH India supplies Melatonin Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Melatonin Al belongs to the melatonin receptor agonist class and is used to manage sleep‑related disorders.

  • Insomnia: helps initiate and maintain sleep, improving sleep quality in individuals with difficulty falling asleep.
  • Jet lag: assists the body’s circadian adjustment after rapid time‑zone travel, reducing sleep disruption.
  • Sleep‑wake rhythm disorders: stabilises abnormal sleep patterns, supporting a regular sleep‑wake cycle.

How It Works

  • Melatonin acts as an agonist at the MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone that regulates circadian rhythms. By binding these receptors, it signals the body that nighttime has arrived, promoting the physiological processes that lead to sleep onset and maintenance without directly affecting other neurotransmitter systems.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea or mild gastrointestinal discomfort
  • Vivid dreams or altered dream patterns
  • Mild abdominal cramps

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching or swelling
  • Severe dizziness or vertigo
  • Mood changes including depression or anxiety
  • Hallucinations or vivid nightmares
  • Respiratory depression (rare)
  • Severe abdominal pain or vomiting

Precautions & Warnings

Melatonin should be used with consideration of individual health status and concomitant therapies.

  • Assess medical history: evaluate existing sleep disorders and comorbid conditions before use.
  • Review concomitant medications: check for potential additive CNS depressant effects.
  • Avoid use in children unless specifically prescribed: safety data in pediatric populations are limited.
  • Use caution in hepatic impairment: metabolism may be altered, requiring monitoring.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Melatonin may interact with other agents that affect the central nervous system or metabolic pathways.

Major Interactions (Avoid)

  • Benzodiazepines or other sedatives: risk of excessive sedation.
  • Anticoagulants (e.g., warfarin): possible increase in bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may alter drug levels.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance drowsiness.
  • Antihistamines: may increase sedation.
  • Oral contraceptives: melatonin may affect hormone metabolism.

Frequently Asked Questions

Melatonin Al contains melatonin, a hormone that helps regulate the body’s sleep‑wake cycle. It is used to treat insomnia, reduce the effects of jet lag after rapid travel across time zones, and manage other sleep‑wake rhythm disorders by promoting the onset of sleep.

Melatonin binds to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, the central clock that controls circadian rhythms. Activation of these receptors signals nighttime, helping to synchronize internal biological rhythms and facilitate the transition to sleep.

The appropriate dose of Melatonin Al is determined by a prescriber based on the individual’s age, condition, and response. Healthcare professionals consider factors such as the severity of insomnia or the number of time zones crossed when recommending a specific regimen.

Safety data for melatonin use during pregnancy or lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Melatonin Al.

To request Melatonin Al, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike prescription hypnotics that act on GABA receptors, melatonin works by mimicking the natural sleep hormone and resetting circadian rhythms. This mechanism generally results in fewer next‑day residual effects, but its efficacy may be more modest for severe insomnia compared with stronger sedative agents.

Melatonin Al should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its potency throughout its shelf life.

Melatonin Al is taken orally, usually as a tablet or capsule, with water. It is typically taken shortly before bedtime, following the dosage instructions provided by the prescribing clinician.

Serious but rare risks include severe allergic reactions such as rash, itching, swelling, or difficulty breathing, and rare cases of pronounced dizziness or mood changes. Patients should seek immediate medical attention if they experience any of these symptoms.

Melatonin Al is not recommended for individuals with known hypersensitivity to melatonin, for children unless specifically prescribed, or for patients with uncontrolled severe hepatic impairment without medical supervision. Anyone with a complex medical history should consult a healthcare professional before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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