Product image of Melatonin Bluefish (Melatonin) supplied by GNH India

Melatonin Bluefish

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Bluefish (Melatonin)

Melatonin, the active ingredient in Melatonin Bluefish, is a melatonin receptor agonist presented as an oral supplement for oral use. It is used to help regulate the sleep‑wake cycle and is indicated for adults experiencing insomnia, jet lag, or other circadian rhythm disturbances.

GNH India supplies Melatonin Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU quality standards and is manufactured under GMP conditions, ensuring consistent potency and purity for global distribution. It is available for bulk and unit‑dose procurement to meet diverse market needs.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Melatonin acts on melatonin receptors to support normal circadian rhythm and sleep regulation.

  • Insomnia: reduces sleep onset latency and improves total sleep time in adults.
  • Jet lag: helps synchronize the internal clock after rapid time‑zone travel.
  • Sleep‑wake cycle disorders: stabilises disrupted sleep patterns in shift‑workers or individuals with delayed sleep phase syndrome.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. This interaction modulates the circadian signaling cascade, lowering neuronal activity that promotes wakefulness and facilitating the transition to sleep, thereby supporting normal sleep onset and maintenance.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams or nightmares
  • Mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Allergic reactions (rash, itching, swelling)
  • Severe skin eruption (Stevens‑Johnson syndrome)
  • Mood changes (depression, irritability)
  • Hallucinations or confusion
  • Significant blood‑pressure alterations
  • Rare cases of seizures

Precautions & Warnings

When considering melatonin therapy, several safety points should be reviewed.

  • Assess underlying sleep disorder: confirm that melatonin is appropriate for the specific condition.
  • Review concomitant medications: evaluate potential interactions with anticoagulants, CNS depressants, or CYP1A2 inhibitors.
  • Avoid use in children unless specifically advised by a paediatric specialist.
  • Monitor for excessive daytime sleepiness or mood changes, especially during the initial weeks of therapy.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other medicines that influence its metabolism or pharmacodynamic effects.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may increase melatonin plasma concentrations.
  • Anticoagulants (e.g., warfarin): may enhance anticoagulant effect and increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, barbiturates): additive sedation.
  • Immunosuppressants (e.g., cyclosporine): possible alteration of melatonin metabolism.
  • Oral contraceptives: may raise melatonin levels, requiring observation for heightened effects.

Frequently Asked Questions

Melatonin Bluefish contains melatonin, a hormone that helps regulate the sleep‑wake cycle. It is used to manage insomnia, reduce the effects of jet lag after rapid travel across time zones, and treat other circadian rhythm disturbances such as shift‑work sleep disorder.

Melatonin binds to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, mimicking the body’s natural night‑time hormone. This signaling reduces neuronal activity that promotes wakefulness, facilitating the onset of sleep and helping to synchronize the internal clock with external light‑dark cycles.

The appropriate dose of Melatonin Bluefish is determined by the prescribing clinician based on the patient’s age, condition, and response. Healthcare professionals set the regimen, and patients should follow the specific instructions provided by their prescriber.

Safety data for melatonin use in pregnancy and lactation are limited. It is generally advised that pregnant or breastfeeding individuals discuss potential risks with their healthcare provider before starting melatonin therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by restoring the natural hormonal signal that regulates circadian rhythms. This mechanism generally results in fewer cognitive side effects, but efficacy may be modest for severe insomnia, where stronger agents might be preferred.

Melatonin Bluefish should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain potency.

The product is formulated for oral administration. Patients typically swallow the tablet or capsule with a glass of water, preferably 30‑60 minutes before bedtime, unless the prescriber advises a different timing.

Serious but rare risks include severe allergic reactions such as rash, swelling, or Stevens‑Johnson syndrome, as well as significant mood changes like depression or hallucinations. Any sudden or severe symptoms should prompt immediate medical evaluation.

Melatonin should be avoided in individuals with known hypersensitivity to melatonin, in children unless specifically prescribed, and in patients taking medications that have major interactions (e.g., strong CYP1A2 inhibitors or anticoagulants) without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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