Product image of Melatonin Evolan (Melatonin) supplied by GNH India

Melatonin Evolan

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Evolan (Melatonin)

Melatonin, the active ingredient in Melatonin Evolan, is a melatonin receptor agonist presented as an oral formulation for oral use. It helps regulate the sleep‑wake cycle and is used to support sleep onset in adults who have difficulty falling asleep.

GNH India supplies Melatonin Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Melatonin acts on the MT1 and MT2 receptors to influence circadian rhythm disorders.
  • Insomnia: assists adults in initiating sleep more quickly.
  • Delayed Sleep Phase Disorder: helps shift the sleep window earlier.
  • Jet Lag: facilitates adjustment of the internal clock after rapid time‑zone travel.

How It Works

  • Melatonin binds to melatonin MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. This interaction modulates the circadian signaling pathway, reducing neuronal activity that promotes wakefulness and thereby facilitating the transition to sleep.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Dizziness: transient sensation of light‑headedness.
  • Daytime sleepiness: occasional lingering drowsiness.
  • Nausea: mild gastrointestinal upset.
  • Mood changes: slight irritability or emotional variability.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Worsening depression: increased depressive symptoms in susceptible individuals.
  • Severe daytime drowsiness: excessive sleepiness affecting daily activities.
  • Hallucinations: rare visual or auditory disturbances.
  • Hypotension: unexpected drop in blood pressure.

Precautions & Warnings

Before using Melatonin Evolan, consider the following safety measures.

  • Assess suitability: confirm the sleep disorder and evaluate underlying causes.
  • Driving caution: avoid operating machinery if daytime drowsiness occurs.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Pediatric use: not recommended for children unless specifically prescribed.
  • Concomitant sedatives: avoid combining with other CNS depressants without medical advice.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • CNS depressants: concurrent use with benzodiazepines or barbiturates can enhance sedation.
  • Anticoagulants: may increase bleeding risk when taken with warfarin.
  • Immunosuppressants: can reduce the effectiveness of drugs like cyclosporine.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal contraceptive efficacy.
  • Antidepressants (SSRIs): potential for increased serotonin syndrome risk.
  • Caffeine: may counteract melatonin’s sleep‑promoting effect.

Frequently Asked Questions

Melatonin Evolan contains melatonin, a hormone that helps regulate the sleep‑wake cycle. It is used to support adults who have difficulty falling asleep, to treat delayed sleep phase disorder, and to aid adjustment after rapid travel across time zones (jet lag).

Melatonin binds to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, signaling that it is nighttime. This reduces neuronal activity that promotes wakefulness, helping to synchronize the internal clock and promote the onset of sleep.

The appropriate dose of Melatonin Evolan is determined by a prescriber based on the individual’s age, health status, and specific sleep condition. Patients should follow the dosing instructions provided by their healthcare professional.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Melatonin Evolan.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by mimicking the body’s natural hormone to reset circadian rhythms. This mechanism generally results in fewer next‑day sedation effects, but efficacy may vary depending on the underlying sleep disorder.

Melatonin Evolan should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed.

Melatonin Evolan is taken orally, typically as a tablet or capsule, with water. It is usually taken shortly before bedtime, following the dosage instructions given by a healthcare professional.

Serious risks, though rare, include severe allergic reactions (rash, swelling, breathing difficulty) and worsening of depressive symptoms. Patients should seek immediate medical attention if they experience any signs of an allergic response or a marked change in mood.

Individuals with known hypersensitivity to melatonin, those taking interacting CNS depressants without medical supervision, and patients with uncontrolled severe liver disease should avoid using Melatonin Evolan unless directed otherwise by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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