Product image of Melatonin Glenmark (Melatonin) supplied by GNH India

Melatonin Glenmark

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Glenmark (Melatonin)

Melatonin, the active ingredient in Melatonin Glenmark, is a melatonin receptor agonist presented as an oral dosage form for oral use. It helps regulate the sleep‑wake cycle and is used to manage sleep disorders in adults and children. The product is manufactured under EU standards and is intended for short‑term use to improve sleep onset and quality.

GNH India supplies Melatonin Glenmark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

Melatonin Glenmark acts on the melatonin receptor pathway to address disorders of the sleep‑wake cycle.

  • Insomnia: helps reduce time to fall asleep and improve sleep quality.
  • Delayed sleep phase disorder: assists in advancing circadian timing to normalize sleep onset.
  • Jet lag: supports adaptation to new time zones by synchronizing circadian rhythms.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. Activation of these G‑protein‑coupled receptors reduces neuronal firing during the night, promoting sleep onset and helping to reset the circadian clock. By enhancing the physiological night signal, the drug facilitates alignment of the internal rhythm with the external light‑dark cycle.

Side Effects

Adverse reactions reported with melatonin are generally mild and dose‑related.

Common Side Effects

  • Drowsiness: feeling of sleepiness during daytime.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.
  • Gastrointestinal discomfort: nausea or abdominal cramps.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Mood changes: depression or increased anxiety.
  • Hormonal effects: alterations in reproductive hormone levels (rare).

Precautions & Warnings

When considering melatonin therapy, several safety considerations should be observed.

  • Assess underlying conditions: evaluate for depression, seizure disorders, or severe hepatic impairment.
  • Age considerations: use caution in children and the elderly, adjusting dose as advised.
  • Concomitant medications: review use of CNS depressants, anticoagulants, or immunosuppressants.
  • Pregnancy and lactation: avoid unless benefits outweigh potential risks.
  • Driving and machinery: do not operate heavy equipment if drowsiness occurs.
  • Store at room temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Melatonin may interact with other agents that affect its metabolism or pharmacodynamic profile.

Major Interactions (Avoid)

  • Anticoagulants: may increase bleeding risk.
  • Immunosuppressants: could reduce efficacy of melatonin’s immunomodulatory actions.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, alcohol): additive sedative effect.
  • CYP1A2 inhibitors (fluvoxamine, ciprofloxacin): may raise melatonin plasma levels.
  • CYP1A2 inducers (rifampicin, smoking): may lower melatonin exposure.
  • Hormonal contraceptives: may alter melatonin metabolism.

Frequently Asked Questions

Melatonin Glenmark is used to help regulate the sleep‑wake cycle in individuals with sleep disorders such as insomnia, delayed sleep phase disorder, and jet lag. By providing an exogenous source of melatonin, it supports the natural circadian rhythm and can improve sleep onset and overall sleep quality when taken as directed by a healthcare professional.

Melatonin acts as an agonist at the MT1 and MT2 receptors located in the suprachiasmatic nucleus of the brain. Activation of these receptors mimics the body’s natural night‑time hormone signal, reducing neuronal activity that promotes wakefulness and facilitating the transition to sleep. This mechanism helps to synchronize the internal clock with external light‑dark cues.

The appropriate dose of Melatonin Glenmark is determined by the prescribing clinician based on the patient’s age, specific sleep condition, and overall health status. Dosage may vary widely, and patients should follow the exact instructions provided by their healthcare provider without self‑adjusting the amount.

Safety data for melatonin use in pregnancy and lactation are limited. It is generally recommended to avoid routine use unless the potential benefits clearly outweigh any possible risks, and only under direct medical supervision. Pregnant or nursing individuals should discuss alternatives with their healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After receiving the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Melatonin Glenmark differs from traditional sedative hypnotics such as benzodiazepines or Z‑drugs because it works by mimicking a natural hormone rather than depressing central nervous system activity. This generally results in a lower risk of dependence and fewer cognitive side effects, though its efficacy may be more modest for severe insomnia. It is often preferred for circadian‑related sleep disturbances.

Melatonin Glenmark should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

The product is taken orally, typically with a glass of water. It is usually recommended to ingest the dose shortly before the intended bedtime, following the timing instructions provided by the prescribing clinician to align with the natural rise in endogenous melatonin.

Serious adverse reactions, although rare, can include allergic responses such as rash, swelling, or anaphylaxis, as well as significant mood alterations like depression or heightened anxiety. In rare cases, hormonal disturbances affecting reproductive function have been reported. Patients should seek immediate medical attention if they experience any of these symptoms.

Individuals with known hypersensitivity to melatonin or any excipients in the formulation should avoid the product. It is also contraindicated in patients with uncontrolled severe hepatic impairment, those taking certain interacting medications without medical supervision, and in pregnant or nursing women unless a healthcare professional determines that the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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