Product image of Melatonin Glenmark (Melatonin) supplied by GNH India

Melatonin Glenmark

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Glenmark (Melatonin)

Melatonin, the active ingredient in Melatonin Glenmark, is a melatonin receptor agonist presented as an oral product for oral use. It helps regulate the circadian rhythm and is used to support sleep in adults.

GNH India supplies Melatonin Glenmark as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glenmark Arzneimittel Gmbh

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Indications & Clinical Uses

Melatonin acts on the melatonin receptor pathway to address sleep‑wake rhythm disorders.

  • Insomnia (adult): helps reduce sleep onset latency and improve overall sleep quality.
  • Jet lag (travelers): assists the body in adjusting its internal clock after crossing time zones.
  • Shift work disorder (shift workers): supports alignment of sleep timing with irregular work schedules.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking the endogenous hormone. This agonist activity synchronizes the circadian clock, promotes the onset of sleep, and modulates downstream hormonal and physiological processes that regulate the sleep‑wake cycle.

Side Effects

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or daytime sleepiness
  • Headache
  • Dizziness
  • Nausea or mild gastrointestinal discomfort
  • Vivid dreams or nightmares
  • Mild fatigue

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching or anaphylaxis
  • Mood changes including depression or agitation
  • Seizures (rare)
  • Severe hypotension or cardiovascular effects
  • Hepatic enzyme alterations (rare)
  • Persistent tachycardia

Precautions & Warnings

When using Melatonin Glenmark, consider the following safety measures.

  • Pregnancy: safety not established; consult a healthcare professional before use.
  • Breastfeeding: limited data; use with caution and professional guidance.
  • Concomitant CNS depressants: may increase sedation; monitor patient response.
  • Elderly patients: start with the lowest effective dose to reduce risk of excessive drowsiness.
  • Patients with autoimmune disorders: monitor for potential disease activity changes.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Melatonin can interact with several medication classes; awareness of the interaction level is important.

Major Interactions (Avoid)

  • Warfarin (anticoagulant): may increase bleeding risk.
  • Cyclosporine (immunosuppressant): may reduce immunosuppressive efficacy.
  • Fluoxetine or other CYP1A2 inhibitors: can raise melatonin plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines or other CNS depressants: additive sedative effect.
  • Antihypertensive agents: potential enhancement of blood pressure lowering.
  • Oral contraceptives: may increase circulating melatonin levels.

Frequently Asked Questions

Melatonin Glenmark is used to support the regulation of the sleep‑wake cycle. It is commonly prescribed for adult insomnia, jet lag after long‑distance travel, and shift work disorder to help align sleep timing with work or travel schedules.

Melatonin acts as an agonist at the MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. By mimicking the natural hormone, it signals the body that it is nighttime, helping to synchronize the circadian rhythm and promote the onset of sleep.

The appropriate dose of Melatonin Glenmark is determined by the prescribing clinician based on the individual’s age, condition, and response. Dosage may vary, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by directly influencing the body’s circadian clock. This mechanism often results in fewer next‑day residual effects, making it a preferred option for short‑term sleep timing adjustments such as jet lag or shift work.

Melatonin Glenmark should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The product is taken orally, typically with a glass of water. It is usually recommended to ingest the dose shortly before the desired bedtime, following the timing guidance given by the prescribing clinician.

Serious but rare risks include severe allergic reactions such as rash, itching, or anaphylaxis, as well as mood alterations like depression or agitation. Patients should seek immediate medical attention if they experience any signs of an allergic response or significant mood changes.

Individuals with known hypersensitivity to melatonin or any excipients in the formulation should avoid use. Additionally, patients taking certain medications that strongly interact with melatonin, such as specific anticoagulants or CYP1A2 inhibitors, should consult their healthcare provider before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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