Melatonin Glenmark (Melatonin)

• Melatonin Glenmark acts on the melatonin signaling pathway to address sleep‑related disorders.
• Jet lag: helps synchronize the internal clock after rapid time‑zone travel, improving sleep onset and quality.
• Shift work disorder: reduces difficulty falling asleep during daytime hours for individuals working non‑standard schedules.
• Primary insomnia in adults: may shorten sleep latency and increase total sleep time when used as part of a sleep‑hygiene regimen.

• Melatonin Glenmark contains melatonin, which binds to MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to a phase‑shift of the circadian clock and promotion of sleep onset. By mimicking the endogenous hormone, the product reinforces the physiological signal that signals darkness, thereby facilitating the transition to sleep.

Melatonin Glenmark may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Drowsiness
• Headache
• Dizziness
• Nausea
• Mild abdominal discomfort
• Vivid dreams

Serious or Rare Side Effects

• Allergic reactions such as rash, itching or swelling
• Severe daytime sleepiness affecting alertness
• Mood alterations including depression or agitation
• Hallucinations or psychotic symptoms
• Seizures (rare)

• Before using Melatonin Glenmark, consider the following precautions to ensure safe and effective use.
• Pregnancy: consult a healthcare professional before use, as safety data are limited.
• Breastfeeding: discuss potential risks with a physician, as melatonin may be excreted in milk.
• Underlying medical conditions: use caution in patients with epilepsy, depression, or severe liver impairment.
• Concomitant medications: review all current drugs for possible interactions, especially CNS depressants.
• Driving and operating machinery: avoid activities requiring full alertness if residual drowsiness occurs.
• Store at ambient temperature: keep in the original container, protect from moisture and light.

Melatonin Glenmark can interact with other medicines; some combinations require avoidance while others need monitoring.

Major Interactions (Avoid)

• Fluoxetine or other strong CYP1A2 inhibitors: may increase melatonin plasma concentrations and risk of adverse effects.
• Central nervous system depressants (e.g., benzodiazepines, barbiturates): additive sedative effect leading to excessive drowsiness.
• Anticoagulants (e.g., warfarin): potential enhancement of bleeding risk.

Moderate Interactions (Monitor Closely)

• Antihypertensive agents: melatonin may augment blood‑pressure‑lowering effect, requiring monitoring.
• Oral contraceptives: may raise melatonin levels, possibly increasing side‑effect likelihood.
• Antidepressants (SSRIs, SNRIs): may increase risk of serotonin‑related effects; monitor for mood changes.