Product image of Melatonin Medice (Melatonin) supplied by GNH India

Melatonin Medice

Active Ingredient:
Melatonin
Origin:
EU

Melatonin Medice (Melatonin)

Melatonin, the active ingredient in Melatonin Medice, is a melatonin receptor agonist presented as an oral dosage form for oral use. It is used to support the regulation of sleep‑wake cycles in adults experiencing difficulty initiating or maintaining sleep.
GNH India supplies Melatonin Medice as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medice Arzneimittel Pütter Gmbh & Co. Kg

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Indications & Clinical Uses

Melatonin Medice acts on the melatonin MT1 and MT2 receptors to help normalize circadian rhythm disturbances.

  • Insomnia: reduces sleep onset latency and improves sleep continuity.
  • Jet lag: facilitates adjustment of the internal clock after rapid time‑zone travel.
  • Shift work disorder: enhances daytime alertness and nighttime sleep quality for workers on rotating schedules.

How It Works

  • Melatonin binds selectively to MT1 and MT2 receptors in the suprachiasmatic nucleus, mimicking endogenous melatonin. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to phase‑shift of the circadian pacemaker and promotion of sleep onset. The overall effect is a synchronization of the body's internal clock with the external light‑dark cycle.

Side Effects

Melatonin Medice is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness or daytime sleepiness.
  • Headache.
  • Dizziness.
  • Nausea.
  • Mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling.
  • Mood changes including depression or irritability.
  • Rare cases of vivid dreams or nightmares.

Precautions & Warnings

Melatonin should be used with consideration of individual health status and concomitant therapies.

  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Breastfeeding: discuss potential risks with a clinician.
  • Interaction with anticoagulants: monitor coagulation parameters if used concurrently.
  • Underlying psychiatric conditions: use caution in patients with depression or bipolar disorder.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may interact with several medication classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): potential alteration of drug levels.

Moderate Interactions (Monitor Closely)

  • Sedatives or CNS depressants: additive drowsiness.
  • Oral contraceptives: possible reduction in melatonin efficacy.
  • Antidepressants (e.g., SSRIs): may enhance serotonergic effects.

Frequently Asked Questions

Melatonin Medice is used to support the regulation of sleep‑wake cycles in adults who have difficulty falling asleep, experience jet lag after rapid travel across time zones, or work irregular hours that disrupt normal circadian rhythms.

Melatonin acts as an agonist at the MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus. By binding these receptors, it helps synchronize the internal clock with the external light‑dark cycle, promoting sleep onset and improving overall sleep quality.

The appropriate dose of Melatonin Medice is determined by the prescribing clinician based on the individual’s age, condition, and response to therapy. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by mimicking the body’s natural hormone to reset circadian rhythms. This mechanism often results in fewer next‑day residual effects, making it a preferred option for short‑term management of sleep onset difficulties and jet lag.

Melatonin Medice should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain potency throughout its shelf life.

Melatonin Medice is taken orally, typically with a glass of water. It is usually administered shortly before the intended bedtime to align with the natural rise in endogenous melatonin levels.

Serious risks, though rare, include allergic reactions such as rash, swelling, or difficulty breathing, and significant mood changes like depression or irritability. Patients should seek immediate medical attention if any of these symptoms occur.

Individuals with known hypersensitivity to melatonin, those taking certain anticoagulants or immunosuppressants without medical supervision, and patients with uncontrolled psychiatric disorders should avoid using Melatonin Medice unless advised otherwise by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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