Melatonin

Melatonin acts as an agonist at the MT1 and MT2 receptors in the suprachiasmatic nucleus of the brain. By activating these receptors, it helps synchronize the internal clock with external light‑dark cycles, promoting the onset of sleep and regulating the timing of the sleep‑wake cycle.

The appropriate dose of melatonin is determined by a prescriber based on the individual’s age, condition being treated, and response to therapy. Dosage may range from low microgram amounts to higher milligram strengths, and the prescribing clinician will provide specific instructions.

Safety data for melatonin use in pregnancy and lactation are limited. Because the potential risks are not well defined, it is generally recommended that pregnant or breastfeeding individuals consult their healthcare provider before starting melatonin.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Unlike many prescription hypnotics that act on GABA receptors, melatonin works by mimicking the body’s natural hormone to regulate circadian rhythms. It is generally considered to have a milder side‑effect profile and is available over the counter in many regions, making it a preferred option for short‑term sleep disturbances and jet‑lag management.

Melatonin should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keeping the product in a dry, cool place helps maintain its potency throughout its shelf life.

Melatonin is taken orally, typically as a tablet or capsule. It is usually taken shortly before bedtime, or as directed by a healthcare professional, to align with the individual’s intended sleep schedule.

Serious but rare risks include severe allergic reactions such as rash, swelling, or Stevens‑Johnson syndrome, as well as mood alterations like depression or anxiety, and, in predisposed individuals, seizure activity. Any concerning symptoms should prompt immediate medical evaluation.

Melatonin should be avoided or used with caution in individuals with known hypersensitivity to the product, uncontrolled epilepsy, severe depression, or those taking medications that may cause significant interactions, such as certain anticoagulants, immunosuppressants, or strong CYP1A2 inhibitors. Consultation with a healthcare provider is essential.