Melatonin Orifarm (Melatonin)

• Melatonin Orifarm acts on melatonin receptors to address disorders of the sleep‑wake cycle.
• Sleep onset insomnia: facilitates faster sleep initiation in adults with difficulty falling asleep.
• Jet lag: reduces the time needed to adjust to new time zones after rapid travel.
• Circadian rhythm sleep disorders: helps synchronize abnormal internal clocks to a normal pattern.

• Melatonin Orifarm contains melatonin, which binds to MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus. Activation of these G‑protein‑coupled receptors modulates circadian signaling, decreases neuronal firing during the night, and promotes the physiological processes that initiate sleep. By mimicking endogenous melatonin, the drug helps reset the internal clock and supports normal sleep onset. The effect is dose‑dependent and typically peaks within an hour after oral administration.

Melatonin Orifarm may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Headache: mild throbbing pain that usually resolves spontaneously.
• Dizziness: transient light‑headed sensation, often occurring after the first dose.
• Daytime sleepiness: feeling unusually drowsy during waking hours.
• Nausea: mild stomach upset that typically subsides.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, or angioedema requiring medical attention.
• Severe hypersensitivity: anaphylactic symptoms such as swelling of the throat or difficulty breathing.
• Mood changes: emergence of depression, irritability, or vivid dreams that may affect daily functioning.

Before initiating Melatonin Orifarm, consider the following precautions.

• Confirm diagnosis: ensure the sleep disorder is appropriately identified before initiating therapy.
• Review concomitant CNS depressants: assess risk when used with alcohol, benzodiazepines or antihistamines.
• Assess hepatic function: dose adjustment may be needed in patients with liver impairment.
• Use caution in children: melatonin should only be prescribed for pediatric use when clearly indicated.
• Monitor for allergic reactions: discontinue if rash, swelling or breathing difficulty occurs.
• Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Melatonin Orifarm can interact with several medicines; awareness of the level of interaction helps guide safe use.

Major Interactions (Avoid)

• CNS depressants (e.g., alcohol, benzodiazepines): may increase sedation and impair alertness.
• Anticoagulants (e.g., warfarin): melatonin can enhance anticoagulant effect and raise bleeding risk.
• Anticonvulsants (e.g., carbamazepine): may reduce melatonin plasma levels, decreasing efficacy.

Moderate Interactions (Monitor Closely)

• Selective serotonin reuptake inhibitors (SSRIs): may alter melatonin metabolism, requiring observation.
• Beta‑blockers: can blunt endogenous melatonin secretion, potentially affecting response.
• Oral contraceptives: may increase circulating melatonin concentrations, necessitating monitoring.